构建人工椎间盘组织工程支架  

Constructing a tissue engineered intervertebral disc scaffold

作　　者：张子言[1] 颜华东[1] 佟珅[1] 姜睿[1] 武汉[1] 

机构地区：[1]吉林大学中日联谊医院,吉林省长春市130033

出　　处：《中国组织工程研究》2013年第38期6825-6831,共7页Chinese Journal of Tissue Engineering Research

摘　　要：背景:组织工程技术的发展为已退变椎间盘功能的恢复提供了可能。目的:综述椎间盘组织工程中支架的研究进展。方法:由第一作者检索PubMed数据库中1990-01-01/2012-12-31有关椎间盘组织工程中支架的文献,以"tissue engineering,intervertebral disc,scaffold"为检索词。结果与结论:支架材料是组织工程研究中的一项重要组成部分。椎间盘纤维环支架材料有3大类,包括天然生物材料、人工合成材料及复合材料。椎间盘纤维环支架材料种类繁多,各有优缺点,尚无公认的最合适的支架材料,支架材料选择仍需进一步的实验研究。纳米级生物材料是研究发展的一个必然趋势,另外,利用仿生学原理,在模拟人椎间盘组织的过程中对支架材料进行改进同样是一个发展趋势;此外,可注射型支架同样是另一个研究热点,可注射型支架材料的选择范围主要集中在壳聚糖、Ⅱ型胶原、透明质酸、纤维蛋白、弹性蛋白、藻酸盐身上,目前将壳聚糖作为支架的研究相对较多。BACKGROUND：Advancement in bioengineering based upon tissue engineering techniques may offer the possibility of repairing degenerative intervertebral disc. OBJECTIVE：To summarize the research progress in the scaffolds of tissue engineered intervertebral disc. METHODS：A computer-based retrieval was performed to search manuscripts describing tissue engineered intervertebral disc scaffolds published between January 1st, 1900 and December 31st, 2012 in PubMed database with the key words of“tissue engineering, intervertebral disc, scaffold”in English. RESULTS AND CONCLUSION：Scaffold is an important part of tissue-engineered research. There are three kinds of materials for intervertebral disc scaffolds：natural biomaterials, synthetic materials, and composite materials. A variety of scaffold materials have their own advantages and disadvantages. Up to now, none of these scaffold materials is accepted as the most suitable one. The selection of scaffold materials is stil to be further studied. The study and development of nanoscale biomaterials is an inevitable trend. Otherwise, with the help of bionics, improving scaffolds is also an inexorable trend in progress of simulating human intervertebral disc. Furthermore, injectable scaffold is also an research hot spot, and the selection range of injectable scaffold materials mainly focuses on chitosan, typeⅡcolagen,hyaluronic acid,fibrin,elastin,and alginate.C urrently, studies on chitosan as a scaffold material are relatively more.

关 键 词：生物材料 生物材料综述 椎间盘 组织工程 椎间盘纤维环支架 支架 纳米级生物材料 综述 

分 类 号：R318[医药卫生—生物医学工程]