含生物活性玻璃离子牙膏治疗牙本质过敏症  

Toothpaste containing NovaMin is applied to treat dentine hypersensitivity

作　　者：李婵秀[1] 黄江勇[2] 梁焕友[1] 

机构地区：[1]中山大学附属第三医院口腔科,广东省广州市510630 [2]广州医学院口腔医院修复科,广东省广州市510140

出　　处：《中国组织工程研究》2013年第38期6846-6852,共7页Chinese Journal of Tissue Engineering Research

摘　　要：背景:NovaMin是一种生物活性玻璃离子,其有效成分与唾液发生反应后形成羟基磷灰石晶体沉积在牙齿表面,封闭暴露的牙本质小管,可用于治疗牙本质过敏症。目的:观察龈下刮治和根面平整后含NovaMin生物活性玻璃子牙膏对患牙敏感症的影响。方法:从543例患者中按照纳入和排除标准筛选出96例慢性牙周炎患者参加试验,遵照随机、双盲、对照的原则随机分成2组,进行龈下刮治和根面平整后,试验组用含NovaMin生物活性材料的专效修复抗敏牙膏刷牙,对照组用不含NovaMin生物活性材料的牙膏刷牙。分别在抗敏试验前和抗敏试验后4周采用目测类比疼痛评分评价患牙空气刺激的敏感程度。结果与结论:共88例患者完成试验,两组各44例。使用牙膏4周后,试验组目测类比疼痛评分由抗敏试验前时的4.25±1.87降低至2.53±1.22,试验前后比较差异有显著性意义(P<0.05);对照组目测类比疼痛评分由抗敏试验前时的4.03±1.92降低至3.63±1.45,试验前后比较差异有显著性意义(P<0.05);试验组降低程度较对照组更明显(P<0.05)。表明含NovaMin生物活性玻璃离子的抗敏感牙膏可有效减缓龈下刮治和根面平整术后的牙本质过敏症状。BACKGROUND：NovaMin is a kind of bioactive glass, and its active ingredients react with saliva to form hydroxyapatite crystals, which deposit on the surface of the teeth and can close the exposed dentinal tubules. It can be used for the treatment of dentin hypersensitivity. OBJECTIVE：To study the effect of toothpaste containing NovaMin on tooth hypersensitivity patients after subgingival scaling and root planing surgery. METHODS：According to inclusion and exclusion criteria, 96 patients were picked out from 543 patients to participate in the experiment. In compliance with the principle of randomized, double-blind, comparison, 98 subjects were randomly divided into two groups：experiment group in which the toothpaste containing NovaMin was used, and control group in which the toothpaste without NovaMin was used. Visual analog scale scoring was used to evaluate the degree of sensitivity to air stimulus respectively before and 4 weeks after al ergy experiment. RESULTS AND CONCLUSION：Total y 88 patients completed the experiment. After treatment with toothpaste for 4 weeks, visual analog scale scores in the experiment group decreased from 4.25±1.87 at baseline to 2.53±1.22 by air stimulus, and visual analog scale scores in the control group decreased from 4.03±1.92 at baseline to 3.63±1.45. The visual analog scale scores in the experiment group and control group both reduced, and the difference was with statistics significance （P〈0.05）. Compared with the control group, visual analog scale scores in the experiment group decreased more significantly. It showed that the toothpaste containing NovaMin has significant effect on dentin hypersensitivity after subgingival scaling and root planing surgery.

关 键 词：生物材料 生物材料临床实践 生物活性玻璃离子 牙本质敏感症 龈下刮治 根面平整 目测类比疼痛评分 

分 类 号：R318[医药卫生—生物医学工程]