注射用奥美拉唑在大鼠失血模型体内的药动学  

Pharmacokinetics of omeprazole in rat hemorrhagic model

作　　者：荆俊丽[1] 陈彤 张东梅[1] 闫春雷[1] 苏乐群[3] 王文奇[3] 

机构地区：[1]山东大学药学院,山东济南250012 [2]烟台市食品药品检验所,山东烟台264000 [3]山东省千佛山医院,山东济南250014

出　　处：《中国医院药学杂志》2013年第18期1505-1508,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:研究注射用奥美拉唑在大鼠失血模型体内的药动学变化。方法:32只大鼠随机分为4组,分别为空白对照组(A组)、失血10%组(B组)、失血20%组(C组)和失血30%组(D组),每组8只。大鼠失血模型建立后,对照组和失血组分别尾静脉注射奥美拉唑(10 mg·kg-1),采用高效液相色谱法分析测定奥美拉唑的血浆浓度,利用DAS ver 2.0程序计算其药动学参数。结果:B组与对照组相比,药时曲线下面积(AUC0-t,AUC0-∞)、平均滞留时间(MRT0-t,MRT0-∞)、半衰期(t1/2)、清除率(CL)、表观分布容积(V)各药动学参数差异均无显著性(P>0.05);C组与对照组相比,MRT0-t、MRT0-∞、t1/2均延长(P<0.01),其余参数差异无显著性(P>0.05);D组与对照组相比,MRT0-t、MRT0-∞、t1/2均延长(P<0.01),且V增大(P<0.01),其余参数差异无显著性(P>0.05)。结论:当机体失血20%以上时,可能需要调整注射用奥美拉唑的给药方案,以确保用药的安全性和有效性。OBJECTIVE To study the pharmacokinetics of omeprazole in rat hemorrhagic model. METHODS 32 rats were randomized divided into four groups： control group （A group）, hemorrhage 10% group （B group）, hemorrhage 20% group （C group） and hemorrhage 30% group （D group）, and 8 rats for each group. After hemorrhage model was conducted, all rats were administrated with omeprazole （10 mg＇kg-1） by tail vein injection. Plasma concentration of omeprazole was determined by HPLC and pharmacokinetic parameters were calculated by DAS ver 2. 0. RESULTS Compared with control group, AUG, AUG, , MRTot, MRT0, t/2, CL and V of B group had no significant difference （P〉0. 05）. MRT0 t, MRT,0and 6/2 of C group were longer than control group （P〈0.01）, and the left parameters had no significant difference （P〉0.05）. MRT, MRT0 and h/2 of D group were longer and the parameter V was larger than control group （P〈0. 01 ）. The left pa rameters of D group have no significant difference （P〈0. 05）. CONCLUSION When body lost more than 20% blood, dosage regimen of omeprazole may need adjustment to ensure the safety and effectiveness.

关 键 词：奥美拉唑 失血 药动学 合理用药 

分 类 号：R969.1[医药卫生—药理学]