60例别嘌醇片不良反应/事件报告分析  

Case report and analysis of allopurinol-caused ADR /ADE in 60 patients

作　　者：吴海雯 王春婷[2] 

机构地区：[1]宁波市药品不良反应监测中心,宁波315000 [2]国家药品不良反应监测中心,北京100045

出　　处：《中国新药杂志》2013年第18期2215-2218,共4页Chinese Journal of New Drugs

摘　　要：目的:分析别嘌醇片不良反应/事件(ADR/ADE)发生基本情况,探讨其ADR表现及发生规律,为临床药品ADR监测及合理用药提供参考。方法:对宁波市中心2007-2012年收集到的别嘌醇片ADR/ADE报告进行统计、分析。结果:老年男性患者发生率高,严重报告比例高,严重报告占总报告的60.0%,累及的系统器官主要为皮肤及其附件损害(55.56%)、全身性损害(19.44%)、肝胆系统损害(11.11%),严重皮肤系统的损害以多形红斑型药疹、剥脱性皮炎为主,别嘌醇引起的超敏综合征容易漏诊。结论:别嘌醇片安全使用管理丞待加强,临床应重视别嘌醇的ADR,加强用药监测,确保安全使用。Objective： To investigate the general features of adverse drug reactions （ADRs） caused by al- lopurinol for providing information for ADR monitoring and rational drug use. Methods： ADR reports of allopurinol in 2007 - 2012 were downloaded from Ningbo Center for ADR Monitoring. All items of the report form were collect- ed and analyzed. Results： The adverse reactions occurred more easily in the old men, in whom severe ADRs ac- counted for 60.0% of all reports. In the ADRs, the lesions primarily involved damages in skin and its accessories （ 55.56% ） , systemic damages （ 19.44% ） and hepatobiliary system damage （ 11.11% ）. The severe skin damages were mainly presented as erythema multiforme and exfoliative dermatitis eruption. Conclusion： Management for al- lopurinol use should be strengthened, and adverse reactions should be intervened so as to reduce or avoid the occur- rence of ADR.

关 键 词：别嘌醇 药品不良反应 分析 

分 类 号：R917[医药卫生—药物分析学]