糖尿病患者结核病患病情况及危险因素分析  

Prevalence of tuberculosis and its risk factors among patients with type 2diabetes

作　　者：赵文静[1,2] ShiLi-zheng VivianA.Fonseca HeJiang 邵德成 赵杰 陈清梅[1,2] 尹爱田[1,2] 

机构地区：[1]山东大学卫生管理与政策研究中心,山东济南250012 [2]卫生部卫生经济与政策研究重点实验室 [3]TulaneUniversitySchoolofPublicHealthandTropicalMedicine [4]TulaneUniversitySchoolofMedicine [5]山东省宁阳县结核病防治所 [6]山东省沂水县结核病防治所

出　　处：《中国公共卫生》2013年第10期1413-1416,共4页Chinese Journal of Public Health

基　　金：世界卫生组织西太地区办公室结核病实施性研究基金项目(WPPDCC1002661)

摘　　要：目的 分析糖尿病患者中结核病的患病情况及危险因素,为结核病的早期发现提供参考依据。方法 采用分层随机整群抽样方法对在山东省宁阳县和沂水县24个乡镇518个村筛查出的4 085例糖尿病患者进行结核病的诊断与问卷调查,并采用多因素logistic回归模型对危险因素进行分析。结果 4 085例糖尿病患者中发现结核病患者14例,其中13例为新发病例,1例为复治涂阳病例,糖尿病患者结核病患病率为342.72/10万;不同特征糖尿病患者结核病患病情况比较,不同性别、体质指数、焦虑症状糖尿病患者结核病患病情况差异均有统计学意义（P〈0.05）;多因素logistic回归分析结果表明,男性（OR=5.057,95%CI=1.562~16.377）、体质指数〈18.5 kg/m2（OR=16.189,95%CI=2.588~101.260）、有焦虑症状（OR=5.214,95%CI=1.772~15.339）是糖尿病患者患结核病的危险因素;与糖尿病患者比较,糖尿病合并结核病患者在过去24 h更易出现咳嗽、发热、高热、乏力的症状（均P〈0.05）,在过去1个月更易出现咳嗽、咯痰、高热的症状（均P〈0.05）。结论 糖尿病患者结核病患病率较高,男性、体重较轻、有焦虑症状的糖尿病患者更易患结核病。Objective To examine the prevalence of tuberculosis and its risk factors in diabetic patients for earlier tuberculosis diagnosis.Methods Stratified-cluster random sampling was used to select 4 085 diabetic patients in Ningyang and Yishui county.Tuberculosis diagnosis and questionnaire survey were conducted in the diabetic patients.Relationship between tuberculosis and related risk factors among the diabetic patients were evaluated using logistic regression analysis.Results Totally 14 tuberculosis cases were diagnosed among the 4 085 diabetic patients.The prevalence of tuberculosis in the patients was 342.72/100 000,compared to 42.82/100 000 in the general population.Patients with comorbid diabetes and tuberculosis were more likely to be male,underweight,anxious（P〈0.05 for all）and to have cough,fever,hyperthermia,fatigue in past 24 hours and cough,expectoration and hyperthermia in past one month（P〈0.05 for all）.Conclusion Diabetic patients have a higher rate of developing tuberculosis.Male,underweight and anxious diabetic patients are more likely to have tuberculosis.

关 键 词：结核病 患病情况 糖尿病患者 危险因素 

分 类 号：R183.3[医药卫生—流行病学]