浅谈流感病毒的HA突变与受体识别的关系  

A Brief Instruction about the Relationship between Influenza Virus HA Mutation and Receptor Recognition

作　　者：徐宁[1] 姜楠[1] 孙伟 李翠 

机构地区：[1]辽宁省重大动物疫病应急中心,辽宁沈阳110161 [2]辽宁辉山乳业集团,辽宁沈阳113123 [3]辽宁抚顺市新宾县动物卫生监督管理局,辽宁新宾113200

出　　处：《现代畜牧兽医》2013年第9期37-41,共5页Modern Journal of Animal Husbandry and Veterinary Medicine

摘　　要：近年来,经常发生禽流感病毒由禽类传染给人类的事件,但禽流感病毒在人与人之间却未发生传播,其机制可能是由于流感病毒表面的HA糖蛋白与靶细胞表面的唾液酸受体结合具有特异性。本文主要从A型流感病毒与人类受体结合的特异性、HA氨基酸的突变对禽流感感染人类的影响以及HA突变对流感病毒传播能力的影响等方面初步探讨了流感病毒HA突变与受体识别的关系,以期能为将来人们研究流感病毒的感染和传播机制提供思路。Recently there were more and more influenza virus infect human incident, but there was no infection between human, the mechanism is probable because the spec- ificity between the virus surface HA glycoprotein and the sialic acid receptor on the surface of the target cell. In this article the specificity between type A influ- enza virus and human, the influence of the amino acid mutation of HA and the infec- tion ability influence of the influenza virus with HA mutation has been described. Providing a theory on virus infection and transfer mechanism.

关 键 词：流感 传播 HA突变 受体 

分 类 号：S852.65[农业科学—基础兽医学]