长托宁、阿托品联合血液灌流治疗重症有机磷中毒的临床研究  

Clinical study of Penehyclidine Hydrochloride, Atropine combined with hemoperfusion in the treatment of patients with severe organophosphate poisoning

作　　者：解金洪[1] 赵敏[2] 

机构地区：[1]江苏省南通市中医院急诊内科,江苏南通226001 [2]中国医科大学附属盛京医院内科,辽宁沈阳110004

出　　处：《中国医药导报》2013年第28期87-89,共3页China Medical Herald

基　　金：国家自然科学基金项目(编号81171793)

摘　　要：目的 探讨联合应用长托宁、阿托品和血液灌注治疗重症有机磷中毒临床研究.方法 选择2009年3月～2013年5月江苏南通市中医院收治的重症有机磷中毒患者81例,随机分为治疗组和对照组,对照组采用长托宁联合阿托品治疗,治疗组采用长托宁、阿托品联合血液灌注治疗.观察阿托品化时间、胆碱酯酶恢复时间、中毒症状消失时间、住院时间以及总有效率等指标.结果 治疗组阿托品化时间、胆碱酯酶恢复时间、中毒症状消失时间、住院时间均显著低于对照组（P＜0.05）.治疗组总有效率为95.0％,高于对照组总有效率（75.6％）,差异有统计学意义（P＜0.05）.结论 联合应用长托宁、阿托品和血液灌注治疗重症有机磷中毒疗效显著.Objective To explore the clinical study of the Penehyclidine Hydrochloride,Atropine and hemoperfusion in the treatment of patients with severe organophosphorus poisoning.Methods Totally 81 cases of patients with severe organophosphorus poisoning in Nantong Hospital of Traditional Chinese Medicine of Jiangsu Province from March 2009 to May 2013 were randomly divided into treatment group and control group.Control group was treated with Penehyclidine Hydrochloride and Atropine,and treatment group was treated with Penehyclidine Hydrochloride,Atropine and hemoperfusion.The Atropine time,recovery time of cholinesterase,disappear time of poisoning symptoms,hospitalization time and total effective rate were observed.Results The Atropine time,recovery time of cholinesterase,disappear time of poisoning symptoms and hospitalization time of the treatment group were lower than those of control group （P ＜ 0.05）.The total effective rate was 95.0％ in treatment group,which was higher than that in control group （75.6％）,with a significant difference （P ＜ 0.05）.Conclusion The use of Penehyclidine Hydrochloride,Atropine and hemoperfusion are effective in the treatment of patients with severe organophosphorus poisoning.

关 键 词：长托宁 阿托品 血液灌流 重度有机磷中毒 

分 类 号：R595.4[医药卫生—内科学]