1084例女性TRACP、CTX-1、BALP、BGP、钙磷代谢指标与BMD相关性  

Correlation between BMD and TRACP,CTX-1,BALP,BGP,calcium,and phosphorus in 1084 women

作　　者：张萌萌[1] 张艳会[1] 毛未贤[1] 马倩倩[1] 高远[1] 刘颖[1] 梁斌斌[1] 

机构地区：[1]吉林省骨质疏松诊疗中心(吉林大学第四医院),长春130011

出　　处：《中国骨质疏松杂志》2013年第9期902-906,共5页Chinese Journal of Osteoporosis

基　　金：民政部"十一五"期间老年学研究骨质疏松项目(2007)18-1-01

摘　　要：目的研究女性抗酒石酸酸性磷酸酶（TRACP）、I型胶原交联C-末端肽（CTX-1）、骨碱性磷酸酶（BALP）、骨钙素（BGP）、25-羟维生素D3（25（OH）D3）、甲状旁腺素（PTH）、降钙素（CT）与股骨颈BMD的相关性。方法采用DiscoveuWA型骨密度仪检测股骨颈BMD，采用酶标免疫分析仪检测TRACP、CTX-1、BALP、BGP、25（OH）D3、PTH、CT。将1084例受试者检测结果按5岁为年龄段分组，应用SPSS13．0分析软件进行统计分析。结果25（OH）D3、PTH、CT在35-50岁年龄段各组间不存在差异；50岁以后25（OH）D，开始下降，与BMD呈正相关；CT降低出现在65-79岁年龄段，与BMD显著正相关。35-45岁年龄段TRACP、CTX-1与BMD呈负相关，而BALP、BGP与BMD呈正相关；50-60岁年龄段BALP、BGP明显升高，TRACP、CTX-1、BALP、BGP均与BMD呈负相关；65岁以后BALP、BGP开始下降，BALP、BGP与骨密度呈正相关，TRACP、CTX-1与骨密度呈负相关。结论TRACP、CTX-1、BALP、BGP、25（OH）D3、PTH、CT监测骨代谢水平为骨质疏松诊断、鉴别诊断提供了分子生物学依据。Objective To study the correlation between BMD of the femoral neck and tartrate resistant acid phosphatase （TRACP） , type I collagen carboxy-terminal peptide （ CTX-1 ） , osteocalcin （BGP） , bone specific alkaline phosphatase （BALP） , 25-hydroxy vitamin D3 （25 （OH） D3 ） , parathyrin （PTH） , and ealcitonin （CT） in females. Methods BMD of the femoral neck was detected using a bone mineral density detector （Discovery WA）. Serum concentrations of TRACP, CTX-1, BALP, BGP,..25 （OH）D3, PTH, and CT were detected using an enzyme immunoassay analyzer. The results of 1084 women were divided into different groups according to a 5-year division. A SPSS 13.0 software was used for statistical analysis. Results The values of 25 （OH） D3 , PTH, and CT had no difference in 35-50 age group. However, after the age of 50, the values of 25 （OH） D3 started to decline, which was positively correlated with BMD. The values of CT decreased in the groups of 65-79 years old, which was significantly positively correlated with BMD. The values of TRACP and CTX-1 had negative correlation with BMD in the groups of 35-45 years old, while the values of BALP and BGP had positive correlation with BMD. The values of BALP and BGP increased significantly in the groups of 50-60 years old, and the values of TRACP, CTX-1, BALP, and BGP all had negative correlation with BMD. After the age of 65, the values of BALP and BGP started to decline, and had positive correlation with BMD, and the values of TRACP and CTX-1 had negative correlation with BMD. Conclusion Bone metabolism level of TRACP, CTX-1, BALP, BGP, 25 （OH）D3, PTH, and CT provides molecular biological basis for the diagnosis and differential diagnosis of osteoporosis.

关 键 词：钙磷代谢调节指标（25（OH）D PTH CT） 骨代谢标志物（TRACP CTX 1 BALP BGP） 股骨颈骨密度 相关性 

分 类 号：R473[医药卫生—护理学]