果蝇翅原基发育分化的主要过程及分子机理  

The main processes and molecular mechanisms of wing disc development and differentiation in Drosophila

作　　者：欧俊[1] 郑思春[1] 冯启理[1] 刘琳[1] 

机构地区：[1]华南师范大学生命科学学院,广东省植物发育重点实验室,广州510631

出　　处：《昆虫学报》2013年第8期917-924,共8页Acta Entomologica Sinica

基　　金：国家重点基础研究发展规划项目(2012CB114602);国家自然科学基金项目(31172265)

摘　　要：翅原基发育分化与昆虫的个体发育紧密联系,对昆虫翅发育的研究有助于阐述昆虫的发育过程。另外,翅的形成是一些农林害虫泛滥的主要原因之一,研究翅发育分化有助于我们从翅发育的角度控制农林害虫。目前,翅发育分化在果蝇Drosophila中研究已较为深入详细。果蝇翅发育分化主要包括4个阶段:翅原基(wing disc)的确定,前-后(antero-posterior,A-P)和背-腹(dorso-ventral,D-V)组织中心(organizing center)的建立,翅区(wing region)的确定,以及翅区的进一步分化。具有homeobox序列的基因(homeobox基因)如Engrailed(En)、Apterous(Ap)和Ultrabithorax(Ubx),分泌蛋白如Wnt家族成员Wingless(Wg)及TGF-β超家族成员Decapentaplegic(Dpp)和Hedgehog(Hh),以及翅原基特有的核蛋白编码基因Vestigial(Vg),共同调控了翅原基的正常发育分化。本文综述了果蝇翅原基发育分化的过程及分子机理方面的研究发现,为翅原基的研究提供了参考。The development and differentiation of wing disc is closely related with the ontogeny ot insects, and the study on wing disc is helpful to understand the development of insects. Pests with the ability of flight can cause great loss to agriculture and forestry every year, so the study on the development and differentiation of their wing may help to find new targets to control them. The development and differentiation of wing disc in Drosophila was well elucidated. It includes four main processes ： definition of wing disc, establishment of A-P and D-V organizing centers, definition of wing region, and differentiation of wing region. Homeobox genes [ such as engrailed （ En ） , apterous （ Ap ） , and Ultrabithorax （Ubx）], secretory proteins [ such as Wnt family member Wingless （Wg）, and TGF-I3 superfamily members Deeapentaplegic （Dpp） and Hedgehog （Hh） and wing disc specific nuclear protein coding gene Vestigial （Vg） are involved in normal development and differentiation of wing disc. In this article, the research findings on the development and differentiation of Drosophila wing disc and the related molecular mechanisms were reviewed.

关 键 词：果蝇 翅 翅原基 发育分化 分子调控 homeobox基因 分泌蛋白 

分 类 号：Q965[生物学—昆虫学]