肾素-血管紧张素系统在应激性胰岛功能损伤中的作用  

Role of renin-angiotensin system in stress-related injury of islet function

作　　者：刘春燕[1] 王英之杰[1] 邵加庆[1] 

机构地区：[1]南京大学医学院临床学院(南京军区南京总医院)内分泌科,南京医学硕士210002

出　　处：《医学研究生学报》2013年第9期974-978,共5页Journal of Medical Postgraduates

基　　金：国家自然科学基金(30900697);江苏省医学重点人才项目(RC2011138);南京军区医药卫生科研基金(11MA100)

摘　　要：应激能引起肾素-血管紧张素系统(renin-angiotensin system,RAS)的活化并导致胰岛功能损伤。RAS在胰岛损伤中的作用已被多数学者研究与证实,它能引起氧化应激、胰岛素抵抗、胰岛细胞功能损伤等反应,对胰岛造成严重损害,最终发展为糖尿病。传统治疗糖尿病主要围绕着促进胰岛素分泌和减轻外周胰岛素抵抗,目前,通过应用抑制RAS药物已确切证明了其在降血糖、延缓糖尿病发生发展等方面的作用,为糖尿病的预防和治疗提供新的手段。Stress can activates the renin-angiotensin system （RAS） and causes islets function injury. The role of RAS in injury of islet function has been confirmed by a lot of researches,it can induce oxidative stress, insulin resistance, islet cells damage and finally causes the onset of diabetes. Traditional treatments for diabetes are mainly promoting insulin secretion and reducing peripheral insulin re- sistance. At present, administration of inhibit RAS drugs has already proved its roles in down-regulating blood glucose, delaying the onset and development of diabetes. Therefore,it may provide a new method for the prevention and treatment of diabetes in the future.

关 键 词：应激 肾素-血管紧张素系统 胰岛功能 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]