宁夏地区多囊卵巢综合征患者不同雄激素状态脂代谢特点的比较性分析  

A comparison of lipid metabolism in PCOS patients w ith different testosterone levels in Ningxia Hui Autonomous Region

作　　者：哈灵侠[1,2] 石玉华[1] 赵君利[2] 陈子江[1] 

机构地区：[1]山东大学附属省立医院生殖医学中心,国家辅助生殖与优生工程技术研究中心,生殖内分泌教育部重点实验室,山东省生殖医学重点实验室,济南250021 [2]宁夏医科大学总医院生殖医学中心,银川750004

出　　处：《山东大学学报（医学版）》2013年第9期88-91,共4页Journal of Shandong University:Health Sciences

基　　金：生殖与生育重大疾病诊治的规范化与推广卫生公益性行业科研专项(201002013);国家重点基础研究发展计划(973计划;2011CB944502);国家科技支撑计划(2012BAI32B04);国家自然科学基金(81070461/H0404)

摘　　要：目的探讨宁夏地区多囊卵巢综合征(PCOS)患者高雄激素血症对脂代谢的影响。方法收集PCOS患者267例,其中回族89例,汉族178例,分析高雄激素临床特征。根据血清睾酮水平,将PCOS患者分为高雄激素组和雄激素正常组,比较不同雄激素状态的脂代谢情况。结果①PCOS患者总体、回族、汉族痤疮发生率分别为20.60%、16.85%、22.47%。多毛发生率为25.09%、21.35%、26.97%;高雄激素血症发生率为47.56%、50.56%、46.06%。汉族多毛发生率高于回族(P<0.01)。②在总体PCOS患者中,高雄激素组总胆固醇(CHO)、载脂蛋白B(ApoB)高于雄激素正常组(P<0.05);在汉族PCOS患者中,高雄激素组CHO、低密度脂蛋白(LDL)、ApoB高于雄激素正常组(P<0.05或P<0.01)。在回族PCOS患者中,两组各项指标比较差异无统计学意义(P>0.05)。③在IR正常的非肥胖汉族PCOS患者中,高雄激素组CHO、ApoB高于雄激素正常组(P<0.05)。结论独立于肥胖、胰岛素抵抗因素,高雄激素血症是PCOS患者脂代谢紊乱的危险因素,且回、汉族间存在差异。Objective To explore the effect of hyperandrogenemia on lipid metabolism in patients with polycystic ovary syndrome （PCOS） in Ningxia Hui Autonomous Region. Methods A total of 267 female patients with PCOS （ 178 Han and 89 Hui nationalities） were collected in this study, who were divided into high androgen group and normal an- drogen group according to their blood testosterone levels. And then their clinical characteristics of hyperandrogenemia were analyzed and compared. Results （~） In all ethnic patients, in Hui and Han patients, the incidence of acne was 20.60%, 16.85% and 22.47% ; the incidence of hirsutism was 25.09%, 21.35% and 26.97% ; the incidence of hy- perandrogenemia was 47.56%, 50.56% and 46.06%, respectively. Hirsutism was more common in Han group than in Hui group （ P 〈 0.01 ）. （~） In all ethnic patients, the total cholesterol （CHO） and apolipoprotein （ ApoB ） were signifi- cantly higher in the hyperandrogenemia group than in normal androgen group （P 〈 0.05 ）. In Han patients, CHO, low- density lipoprotein （LDL） and ApoB were significantly higher in the hyperandrogenemia group than in normal androgen group （P 〈0.05 or P 〈0.0l）. In Hui patients, there was no significant difference between the two groups （P 〉0.05）. （~） In the non-obesity Han group with non-IR, CHO and ApoB were significantly higher in the hyperandrogenemia group than in normal androgen group （ P 〈 0.05 ）. Conclusion Hyperandrogenemia is the risk factor for dyslipidemia in women with PCOS, independent of obesity and insulin resistance. However, there exist differences between Hui and Han groups.

关 键 词：多囊卵巢综合征 高雄激素血症 脂代谢 肥胖 胰岛素抵抗 

分 类 号：R711.6[医药卫生—妇产科学]