低分子肝素对兔动脉粥样硬化易损斑块模型血清CRP、IL-6的影响  

Effect of low molecular weight heparin on serum C-reactive protein and IL-6 levels of vulnerable plaque in rabbits

作　　者：胡大军[1,2] 刘剑萍[3] 廖昆[3] 贺立新[3] 

机构地区：[1]湘南学院心脑血管疾病研究所 [2]郴州市人民医院心内科,湖南郴州423000 [3]湘南学院

出　　处：《中国老年学杂志》2013年第18期4468-4469,共2页Chinese Journal of Gerontology

基　　金：湖南省教育厅资助项目〔No.06C777〕;湖南省高等学校科学研究项目(2006年)

摘　　要：目的探讨低分子肝素在兔动脉粥样硬化易损斑块模型中对炎症因子C反应蛋白(CRP)、白介素-6(IL-6)的影响。方法 31只兔易损斑块模型组随机分为易损斑块模型对照组(n=7)、低分子肝素治疗组(n=16)、辛伐他汀治疗组(n=8),治疗干预1 w后,采用ELISA法观察各组血清CRP、IL-6治疗前后浓度变化。结果低分子肝素治疗组及辛伐他汀治疗易损斑块模型组CRP、IL-6的浓度较治疗前明显下降,同对照组比较有显著差异(P<0.05),但低分子肝素组与辛伐他汀组比较无显著差异。结论低分子肝素治疗后可明显降低兔易损斑块模型组血清CRP、IL-6浓度。Objective To observe the effect of low molecular weight heparin （LMWH） on serum C-reactive protein （CRP） and IL- 6 levels of vulnerable plaque in rabbits. Methods 31 male health rabbits were divided randomly into control （ n = 7 ） , LMWH （ n = 16 ） , simvastatin groups （ n = 8）. After7 days, the rabbit blood was taken to detect IL-6 and CRP by ELISI. Results Compared with the group of model, the level of serum IL-6 and CRP were decreased significantly in the LMWH and simvastatin groups （P 〈 0. 01 ）. However, there was no significant difference between simvastatin and LMWH groups （ P 〉 0. 05）. Conclusions LMWH could reduce serum CRP and IL-6 levels of vulnerable plaque in rabbits.

关 键 词：易损斑块 炎症因子 低分子肝素 

分 类 号：R332[医药卫生—人体生理学]