超声光散射成像对三阴性乳腺癌的诊断价值  

Ultrasound-guided Diffused Optical Tomography in the Diagnosis of Triple-negative Breast Cancer

作　　者：刘灿[1] 张海娴[1] 李丽霞[2] 唐丽玮[1] 孙芳[1] 崔广和[1] 

机构地区：[1]滨州医学院附属医院超声医学科,山东滨州256603 [2]滨州市立医院病理科,山东滨州256600

出　　处：《中国医学影像学杂志》2013年第9期666-668,共3页Chinese Journal of Medical Imaging

基　　金：山东省自然科学基金面上项目(ZR2012HL02)

摘　　要：目的探讨超声光散射断层成像(DOT)诊断三阴性乳腺癌(TNBC)的价值。资料与方法根据雌激素受体(ER)、孕激素受体(PR)和人表皮生长因子受体-2(HER2)的表达将153例乳腺癌患者分为TNBC组(12例)和非TNBC组(141例),比较两组超声及DOT图像特征。结果 TNBC组与非TNBC组的超声BI-RADS分级的诊断准确率分别为25.00%和85.82%,差异有统计学意义(t=26.262,P<0.05);TNBC组血红蛋白总量(HBT)、血氧饱和度(SO2)及DOT BI-RADS分级的诊断准确率分别为91.67%、83.33%、83.33%,非TNBC组HBT、SO2及DOT BI-RADS分级的诊断准确率分别为91.49%、90.07%、90.78%,差异无统计学意义(t=0.694、0.000、0.536,P>0.05)。结论 TNBC在常规超声图像上无特征性表现,在常规超声的基础上结合DOT有助于提高TNBC的诊断准确率。Purpose To discuss the value of ultrasound-guided diffused optical tomography （DOT） in the diagnosis of triple-negative breast cancer （TNBC）. Materials and Methods In terms of expressions of estrogen receptor （ER）, progesterone receptor （PR） and human epidermal growth t：actor receptor 2 （HER2）, 153 patients with breast cancer were divided into TNBC group （12 patients） and non-TNBC group （141 patients）. The ultrasonography and DOT features were analyzed and compared between the two groups. Results The diagnostic accuracy of ultrasound BI-RADS in TNBC group and non-TNBC group showed significant difference （25.00% vs. 85.82%, t-26.262, P〈0.05）, while the diagnostic accuracy of total hemoglobin （HBT）, oxygen saturation （SO_,） and DOT BI-RADS in TNBC group and that in non-TNBC group had no statistic difference （91.67%, 83.33%, and 83,33% ws＇. 91.49%, 90.07%, and 90.78%; t=0.694, 0.000, 0.536, P〉0.05）. Conclusion The ultrasonography of TNBC has no special manifestation; therefore it will be better to combine ultrasonography with DOT to improve the diagnostic accuracy of TN BC.

关 键 词：乳腺肿瘤 超声检查 乳房 光散射成像 受体 雌激素 受体 孕激素 受体 表皮生长因子 

分 类 号：R445.1[医药卫生—影像医学与核医学] R737.9[医药卫生—诊断学]