良性前列腺增生伴组织学炎症与PSA异常升高的相关性  

Correlation of benign prostatic hyperplasia with histological inflammation and elevated prostate-specific antigen

作　　者：孟元[1,2] 卫中庆[1] 熊红兵[3] 黄懿[1] 丁留成[1] 胡明进[2] 

机构地区：[1]南京医科大学第二附属医院泌尿外科,江苏省210011 [2]溧水县人民医院泌尿外科 [3]溧水县人民医院病理科

出　　处：《江苏医药》2013年第17期2016-2018,共3页Jiangsu Medical Journal

基　　金：南京市医学科技发展资金(YKK11187)

摘　　要：目的探讨良性前列腺增生(BPH)伴组织学炎症与前列腺特异性抗原(PSA)异常升高的关系。方法取100例BPH患者前列腺组织行常规HE染色,观察其合并前列腺炎情况。并行免疫组化分析检测炎症相关因子IL-2、类血友病因子(vWF)及其平滑肌α-肌动蛋白(α-SMA)和上皮细胞钙黏蛋白(E-cadherin)指标变化,比较炎症的分级及侵袭度与PSA之间的关系。结果100例BPH患者中,术后病理均认为伴有不同程度的前列腺炎症。相关性分析显示,PSA与前列腺体积、炎症分级、侵袭度分级均呈正相关,炎症分级与α-SMA、E-cadherin呈负相关,与IL-2呈正相关(P均<0.05)。结论 BPH患者都伴随有前列腺炎,PSA与炎症分级、侵袭度分级均有相关性,提示炎症可能是导致前列腺组织增生的原因之一。Objective To investigate the relationship of benign prostatic hyperplasia （BPH） with histological inflammation and elevated serum prostate-specific antigen （PSA）. Methods The conventional HE staining of prostatic tissues was performed in 100 patients with BPH. The histological inflammation was observed and interleukin-2 （IL-2）, smooth muscle actin （a-SMA）, E-cadherin, and von Willebrand factor （vWF） were detected by immunohistochemistry. The relationship of inflammation grade and PSA expression was analyzed. Results The inflammation of the postoperative specimens was diagnosed pathologically in different degrees in all BPH patients. PSA was positively correlated with prostate volume, inflammation and invasion. The inflammation grade was negatively correlated with ^-SMA and E-cadherin, but positively correlated with IL-2. Conclusion BPH patients always have prostatitis. Serum PSA is positively correlated with inflammation and invasion indicating that inflammation may be one of the factors for BPH.

关 键 词：前列腺增生 前列腺特异性抗原 前列腺炎 

分 类 号：R697[医药卫生—泌尿科学]