肾素-血管紧张素系统阻断剂与代谢综合征患者脂联素水平的关系  

Relationship between Renin-Angiotensin System Blockers and Plasma Level of Adiponectin in Patients with Metabolic Syndrome

作　　者：赵姜[1] 吴岩[1] 田凤石[1] 赵紫琴[1] 雒瑢[1] 绳建敏[1] 

机构地区：[1]天津市公安医院,300042

出　　处：《天津医药》2013年第10期968-970,共3页Tianjin Medical Journal

摘　　要：目的探讨肾素-血管紧张素系统(RAS)阻断剂与代谢综合征(Mets)患者血浆脂联素水平的关系。方法53例Mets患者随机分为3组,ACEI组15例予贝那普利(5 mg/d),ARB组15例予坎地沙坦(4 mg/d),对照组23例避免应用影响RAS的相关药物,服药期为4周,检测并比较治疗前后血浆脂联素(APN)、空腹血糖(FBG)、空腹胰岛素(FINS)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、肌酐(CR)、丙氨酸转氨酶(ALT)、胆红素(BIL)和胰岛素抵抗指数(HOMA-IR)的水平。结果ACEI组的FBG和LDL-C、ARB组的CR治疗后低于治疗前(P<0.05);ACEI组和ARB组APN水平治疗后高于治疗前(P<0.01),而3组中FINS、HOMA-IR、TC、ALT和BIL在治疗前后变化差异无统计学意义(P>0.05)。治疗前CR、TC、ALT和BIL是APN水平的影响因素;治疗后FBG和TC是APN水平的影响因素。结论APN可能是ACEI和ARB治疗Mets及其并发症的潜在靶点。Objective To explore the relationship between renin-angiotensin system （RAS） blockers and plasma lev- el of adiponectin （APN） in patients with metabolic syndrome （Mets）. Methods Fifty-three patients with Mets were random- ized into control group （n=23）, angiotensin-convertingenzyme inhibitor （ACEI） group （benidipine, 5 mg/d, n=lS） and angio- tensinll recepter blockers （ARB） group （candesartan, 4 mg/d, n=lS）, and were given 4-week treatment. Twenty-three pa- tients, who were avoiding application related drugs affecting the RAS for four weeks, were used as control. The values of plas- ma APN, fasting blood glucose （FBG）, fasting insulin （FINS）, triglyceride （TG）, high-density lipoprotein cholesterol （HDL- C）, total cholesterol （TC）, low-density lipoprotein cholesterol （LDL-C）, creatinine（CR）, aspartate aminotransferase （ALT）, bil- irubin （BIL） and insulin resistance index （HOMA-IR） were detected and compared before and after treatment. Results The levels of FBG and LDL-C were significantly decreased after treatment than those before treatment in ACEI group. The level of CR was significantly lower after treatment than that before treatment in ARB group （P 〈 0.05）. The plasma APN level was significantly higher after treatment compared to that before treatment in ACEI and ARB groups （P 〈 0.01）.There were no sig- nificant differences in the values of FINS, HOMA-IR, TC, ALT and BIL between ＇before and after treatment＇ in three groups （P 〉 0.05）. The levels of CR, TC, ALT and BIL before treatment were influencing factors for the APN level. The levels of FBG and TC after treatment were influencing factors for the APN level. Conclusion APN may serve as potential therapeu- tic targets for treatina Mets and its related complications by ACEI and ARB.

关 键 词：肾素-血管紧张素系统 血管紧张素转换酶抑制药 脂联素 代谢综合征X 受体 血管紧张素 2型 血管紧张素Ⅱ1型受体拮抗剂 

分 类 号：R972.4[医药卫生—药品]