供卵冻融胚胎移植结局的影响因素分析  

Analysis of Factors Influencing Pregnancy Results of Oocyte-donation Frozen-thawed Embryo Transfer

作　　者：马晓玲[1] 王小飞[1] 张瑞[1] 周燕[1] 张学红[1] 

机构地区：[1]兰州大学第一医院生殖医学专科医院,兰州730000

出　　处：《生殖与避孕》2013年第9期606-609,631,共5页Reproduction and Contraception

摘　　要：目的:探讨卵巢早衰(POF)、卵巢功能低下、染色体异常、反复胚胎种植失败患者在辅助生殖助孕过程中行供卵冻融胚胎移植(FET)的临床疗效。方法:在本院行供卵FET的91个周期为研究组,选择同期常规FET的1 278个周期为对照组,对其妊娠结局进行比较。结果:研究组患者平均移植胚胎数、种植率低于对照组,其中平均移植胚胎数差异有统计学意义(P<0.05);但研究组患者临床妊娠率略高于对照组,且研究组各年龄段的临床妊娠率均略高于对照组,其中≤30岁研究组患者临床妊娠率与对照组相比较,差异有统计学意义(P<0.05)。研究组各年龄组间胚胎种植率、临床妊娠率、流产率、异位妊娠率以及抱婴回家率均无统计学差异;对照组随年龄的增加胚胎种植率、临床妊娠率以及抱婴回家率呈下降趋势,且各年龄组间差异有统计学意义(P<0.05)。研究组中自然周期移植与人工周期相比较,平均移植胚胎数、胚胎种植率、临床妊娠率、流产率、异位妊娠率以及抱婴回家率之间差异均无统计学意义(P>0.05)。结论:供卵FET是治疗POF、遗传性疾病等不能生育健康子代妇女的有效方法;自然周期、激素替代周期均可使种植率和妊娠率达到同样良好的结局。Objective： To analyse the clinical application value of oocyte-donation frozen-thawed embryo transfer （FET） in patients with premature ovarian failure （POF）, decreasing ovarian store （DOS）, genetic factors or multiple assisted reproductive technologies failure. Methods： The pregnancy outcome was observed in 91 cycles performed oocyte-donation FET, with comparison of 1 278 cycles performed with own-oocyte FET as the controls. Results： The age of female patient and duration of infertility in the oocyte-donation FET group were notable higher than those of the own-oocyte FET group, but there was no significant difference in the pregnancy rate, the miscar- riage rate and the ectopic pregnancy rate between the two groups （P〉0.05）. In the oocyte-donation FET group, the implantation rate, the pregnancy rate, the miscarriage rate and the taking baby home rate were not different among different ages, while in own-oocyte FET group the implantation rate, the pregnancy rate and taking baby home rate were falling significantly with the growing of female age （P〈0.05）. The implantation rate and pregnancy rate in oocyte-donation FET group were higher than those in own-oocyte FET group, and the implantation rate in 〈 30- year old group in oocyte-donation FET group was significantly higher. No difference was found between natural cycle and artificial cycle in implantation rate, the pregnancy rate and the miscarriage rate in oocyte-donation FET group. Conclusion： Oocyte-donation IVF-ET is an effective way to help the infertile women with POF and/or genetic diseases. Both natural cycle and artificial cycle could have better pregnancy outcomes.

关 键 词：卵巢早衰（POF） 冻融胚胎移植（FET） 体外受精 胚胎移植（IVF—ET） 妊娠结局 

分 类 号：R714.8[医药卫生—妇产科学]