长链非编码RNAs及其调控血管新生的研究进展  

Research progress of long non-coding RNAs and their role in regulation of angiogenesis

作　　者：刘鹃[1] 汪泱[2] 沈晓黎[1] 邓志锋[1,3] 

机构地区：[1]南昌大学第二附属医院神经外科,南昌330006 [2]上海交通大学附属第六人民医院四肢显微外科研究所,上海200233 [3]上海交通大学附属第六人民医院神经外科,上海200233

出　　处：《上海交通大学学报（医学版）》2013年第9期1301-1305,共5页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(81160154;81272170)~~

摘　　要：长链非编码RNAs(lncRNAs)是在基因组中普遍被转录的一类转录本长度超过200 nt的非编码蛋白RNA。近年来的研究表明,lncRNAs参与了X染色体沉默、基因组印记以及染色质修饰、转录激活、转录干扰和核内运输等多种重要的调控过程,这表明lncRNAs并不是基因组转录的"噪音",而是以RNA的形式在多层面上(表观遗传调控、转录调控以及转录后调控等)调控基因的表达水平。该文总结lncRNAs的功能及其调控血管新生的最新研究进展。Long non-coding RNAs （lncRNAs） are a novel class of non-protein-coding transcript RNAs with more than 200 nt in length, which are pervasively transcribed in the genome. Recent researches have demonstrated that lncRNAs affect many biological processes, including X-inactivation, genomic imprinting, chromatin-modifying, transcriptional activation, transcriptional interference and nuclear-cytoplasmic trafficking, which indicates lncRNAs are not transcriptional noise but functional as a regulater of the gene expression on the epigenetie, transcriptional and post-transcriptional levels. The research progress of lncRNAs functions and their role in the regulation of angiogenesis is reviewed in this paper.

关 键 词：长链非编码RNAs 血管新生 aHIF MEG3 sONE tie-1AS 

分 类 号：R346[医药卫生—基础医学]