二膦酸盐类药物的抗肿瘤作用  

Anti-tumor effect of bisphosphonate drugs

作　　者：靳丽丽[1] 孙晓光[1] 黄钢[1] 

机构地区：[1]上海交通大学医学院附属仁济医院核医学科,上海200127

出　　处：《上海交通大学学报（医学版）》2013年第9期1306-1310,共5页Journal of Shanghai Jiao tong University:Medical Science

摘　　要：二膦酸盐类药物自从被发现具有抑制破骨细胞作用以来,已成为临床上重要的抗骨吸收药物。近年来发现,二膦酸盐类药物也可作用于肿瘤细胞,具有抗肿瘤作用。尤其是与其他抗肿瘤药物的协同作用,使其在临床上能更好地发挥抗肿瘤作用,改善患者的生活质量。该文主要对二膦酸盐类药物的抗肿瘤作用进行综述。Bisphosphonate drugs have become important drugs have inhibitory effect on osteoclasts. Recently, more and more tumor cells, exhibiting the anti-tumor activity. Especially, the for anti-resorption of bone in clinics since they were found to researches propose that bisphosphonate drugs can also affect synergy effect of bisphosphonate drugs and anti-tumor drugs makes bisphosphonate drugs play a better anti-tumor role in clinics, improving the quality of life of patients. This paper reviews the anti-tumor effect of bisphosphonate drugs.

关 键 词：二膦酸盐类药物 抗肿瘤 协同作用 

分 类 号：R965[医药卫生—药理学]