宫颈病变患者人乳头状瘤病毒感染及其亚型分析  

Human papilloma virus infections and subtype analysis of patients with cervical lesions

作　　者：毛小英[1] 徐祥梅[1] 余春兰[1] 何晓燕[1] 

机构地区：[1]浙江省常山县人民医院妇产科,浙江常山县324200

出　　处：《中华医院感染学杂志》2013年第18期4444-4446,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨宫颈病变患者人乳头状瘤病毒(HPV)感染及其亚型分布,为疾病的防治提供客观依据。方法将2010年1月-2012年12月130例宫颈病变患者作为研究对象,运用导流杂交基因芯片技术对患者的宫颈脱落细胞进行21种HPV亚型分析检测。结果 130例宫颈病变患者中有96例发现HPV感染,感染率为73.85%;其中,宫颈炎/尖锐湿疣高危型HPV感染率为54.72%、低危型HPV感染率为15.09%;宫颈上皮内瘤变(CIN)患者高危型及低危型HPV感染率分别为67.69%和7.69%;宫颈癌患者中未发现低危型HPV感染,高危型HPV的感染率高达83.33%;不同宫颈病变患者的高危型、低危型HPV感染率差异有统计学意义(P<0.05);宫颈炎/尖锐湿疣患者中有30例单一感染占56.60%、7例多重感染占13.21%;CIN患者中单一感染和多重感染率分别为60.00%、15.38%,而宫颈癌患者中有8例为单一感染、2例为多重感染,分别占66.67%、16.67%。结论主要型别的高危型HPV持续或多重感染与宫颈癌变有十分密切的关系,应根据宫颈病变患者HPV感染亚型检测结果,及时正确地防治宫颈癌变的进一步加剧。OBJECTIVE To investigate the human papilloma virus infections of patients with cervical lesions and its subtype, so as to provide objective basis for prevention and treatment of diseases. METHODS We selected 130 cases of patients with cervical lesions enrolled from January 2010 to December 2012 as research subjects and detected 21 HPV subtypes of the patientrs cervical exfoliated cells using flow-through hybridization and gene chip technique. RESULTS 96 cases of patients were discovered HPV infections among 130 patients with cervical lesions with an infection rate of 73.85 %. Of which, the high-risk HPV infection rate of gervicitis / genital warts was 54. 72%, and the low-risk HPV infection rate was 15.09%. High-risk HPV infection rate and low-risk HPV infecrate of cervical intraepithelial neoplasia （CIN） in patients were 67.69% and 7.69 %, respectively. The low-risk HPV infections of patients with ervical cancer was not found, and high-risk HPV infection rate was as high as 83.33%. There was significant difference between the high-risk HPV infection rate and low-risk HPV infection rate of different patients with cervical lesions （P〈0.05） ; there were 30 single infection cases in patients with cer- vicitis/genital warts, accounting for 56.60%; seven cases of multiple infections, accounting for 13.21%; single infection and multiple infection rates of CIN patients were 60.00%, 15.38%, respectively. There were 8 patients with single infection, 2 cases with multiple infections in cervical cancer patients, accounting for 66.67%, 16.67% respectively. CONCLUSION The major type of high-risk HPV persistent or multiple infections was closely related to the cervical cancer. It is necessary to prevent the cervical cancer timely based on the HPV infection subtype test results of patients with cervical lesions.

关 键 词：宫颈病变 人乳头状瘤病毒 人乳头状瘤病毒亚型 检测 

分 类 号：R181.32[医药卫生—流行病学]