滋水清肝饮对乳腺癌内分泌治疗不良反应的影响  

Experimental Study of Zishui Qinggan Yin Treat Adverse Effect Caused by Breast Cancer Endocrine Therapy

作　　者：孙少梅[1] 曹鹏[2] 霍介格[2] 胡春萍[2] 王小宁[2] 胡灿红[2] 聂冬辉[1] 

机构地区：[1]南京中医药大学,南京210046 [2]江苏省中医药研究院肿瘤科,南京210028

出　　处：《中国实验方剂学杂志》2013年第18期256-259,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：全国第五批名老中医学术思想继承项目;江苏省名老中医(徐荷芬)工作室建设项目

摘　　要：目的:探讨滋水清肝饮对内分泌治疗后的去卵巢大鼠血清雌激素、血脂及子宫内膜厚度的影响。方法:去卵巢大鼠用来曲唑(0.23 mg·kg-1)建立乳腺癌患者内分泌治疗的类更年期症状模型;大鼠随机分为5组:假手术组、模型对照组、阳性药组(莉芙敏0.026 g·kg-1)、滋水清肝饮(11.28,45.10 g·kg-1)组,去卵巢术后2周开始ig给药,1次/d,连续6周。每7天测量大鼠体重。给药6周后腹主动脉取血,检测雌二醇(E2)、孕酮(内膜厚度PRO)、总胆固醇(CHO)、甘油三酯(TG),高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,镜下观察子宫内膜厚度。结果:滋水清肝饮高、低剂量组体重均低于模型组(P<0.05);滋水清肝饮高剂量组E2,PRO较模型组降低(P<0.05);.滋水清肝饮高剂量组CHO,TG显著降低(P<0.05),高剂量组明显升高LDL-C;滋水清肝饮和莉芙敏组的子宫内膜厚度与模型组无明显差别。结论:滋水清肝饮可以改善内分泌治疗的去卵巢大鼠的血脂,并不会引起雌激素水平的升高和子宫内膜增厚。Objective： To investigate the effect of Zishui Qinggan Yin（ZSQGY） on estrogen level,cholesterol level and the endometrial thickness of ovariectomized rats after endocrine therapy.Method： Ovariectomized rats were treated with Letrozole（0.23 mg·kg-1） to mimic climacteric syndrome of breast cancer patient after endocrine therapy.Rats were randomly divided into five groups（n = 7） and were orally administered corresponding drugs once per day for 6 weeks： sham group,model control group,positive control group（Remifemin 0.026 g·kg-1）,ZSQGY high and low dose group（45.10,11.28 g·kg-1）.The body weight of rats was recorded each week.After the treatment,blood plasma was collected by abdominal aortic method,plasma estradiol（E 2）,progesterone（PRO）,total cholesterol（CHO）,triglycerides（TG）,high density lipoprotein cholesterd（HDL-C）,low density lipoprotein cholesterd（LDL-C） were detected,pathological detection was processed by endometrium thickness.Result： After treatment,the average weight of ZSQGY high and low group were lower than that of model group（P 0.05）.Compared with model group,the serum level of E 2,PRO,CHO,TG,LDL-C of ESQGY were significantly decreased（P 0.05） which were still higher than sham group;the serum level of HDL-C of ESQGY high dose group was incseased（P 0.05）.The ZSQGY groups and remifemin group have no obvious difference in endometrium thickness compared with the model group.Conclusion： ZSQGY can reduce the blood lipid without increasing the E 2,PRO level and endometrium thickness.

关 键 词：滋水清肝饮 去卵巢大鼠 内分泌治疗 更年期症状 

分 类 号：R285.5[医药卫生—中药学]