脂质纳米粒给药系统体外释放方法研究进展  

Development of in vitro Release Methods in Lipid Nanoparticles Drug Delivery System

作　　者：王岚[1] 刘颖[1] 冯年平[1] 

机构地区：[1]上海中医药大学,上海201203

出　　处：《中国实验方剂学杂志》2013年第18期350-356,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：上海市教育委员会预算内科研项目(2010JW12)

摘　　要：通过查阅近几年国内外相关文献,进行归纳整理并分类,介绍了近年来有关经典体外释放方法、透析法、室扩散法、流池法、基于体外脂解模型的体外释放研究方法等体外测定方法在药物释放特性评价中的应用进展。脂质纳米粒给药系统是近年来发展较快的一类药物传递系统,评价脂质纳米粒的指标主要有粒径、Zeta电位、载药量、体外释放、稳定性等。药物释放是影响药物进入体内发挥药效的重要因素之一,故体外释放是评价脂质纳米粒质量的重要指标,也是控制制剂质量的重要手段。但是如何建立一种更加科学合理的体外释放方法使其具有较好的预测性则需要科学工作者进一步研究优化,促进脂质纳米粒给药系统的研究与开发。In this paper, we summarized the development of in-vitro release methods, including typical in vitro release method, dialysis bags or tube diffusion method, Franz diffusion cell method, Flow through cell method, in-vitro release method based on in vitro lipolysis model. Lipid nanoparticles are one of rapid developed drug delivery systems in recent years. The indicators to evaluate the lipid nanoparticles are mainly particle size, Zeta potential, drug loadings, in vitro release, stability and so on. Drug release from the carriers is one of the key factors affecting drug performance in vivo, so the in vitro release is the important one to control the quality of the lipid nanoparticles.

关 键 词：脂质纳米粒给药系统 药物释放 体外释放实验 

分 类 号：R283.6[医药卫生—中药学]