体外受精-胚胎移植妊娠者高凝状态及早期干预后流产率降低的疗效观察  

The occurrence of hypercoagulable state in IVF- ET pregnancy and the lower spontaneous abortion rate after early intervention

作　　者：刘娟[1] 谭宗建[1] 陈朝军[1] 张红云[1] 何峻[1] 

机构地区：[1]贵州省人民医院生殖中心,贵州贵阳550002

出　　处：《中国妇幼保健》2013年第28期4678-4680,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨对体外受精-胚胎移植(IVF-ET)妊娠者高凝状态进行干预降低早期流产率的有效性。方法:选取实施IVF-ET并妊娠的80例患者作为研究对象,检测其凝血功能、D-二聚体及血液流变学指标,观察高凝状态的发生情况,并对高凝状态者早期采用低分子肝素钙及小剂量阿司匹林治疗。以实施IVF-ET但未行抗凝干预的妊娠者51例作为对照组,观察两组间早期流产率的差异。结果:干预组单纯高凝状态(D-二聚体升高伴有部分凝血活酶时间缩短)发生7例(8.8%),血液流变学异常14例(17.5%),二者同时异常为10例(12.5%)。干预组早期流产率为7.5%,对照组为19.6%,两两差异有统计学意义(P<0.05)。结论:低分子肝素钙及阿司匹林干预可有效降低IVF-ET妊娠者的早期自然流产率。Objective： To observe the occurrence of hypercoagulable state in IVF - ET pregnancy and explore the efficacy of the reduction in spontaneous abortion rate after early intervention. Methods： A retrospective analysis was performed on 80 clinical pregnanciesfollowing IVF - ET treatment . Coagulation, D - dimer andhemorheology were detected. The hypercoagulable patients were treated by low - molecular - weight heparin and low - dose aspirin. While the 51 pregnancies following IVF - ET treatment who didn＇ t receive the therapy were selected as control group and the diffirenee between the two groups was observed. Results： 7 cases （ 8.8% ） were abnorma~ in D - dimer and 14 cases （17.5%） in hemorheology. While ll） cases （ 12. 5% ） were both abnormal at the same time. The spontaneous abortion rate was reduced after early intervention. There were significant differences between the two groups. （P 〈 0. 05 ） . Coneluslon： There is high incidence of hypercoagulable state in pregnancy who received IVF- ET, and early intervention with low- molecular- weight heparin and low- dose aspirin can reduce the spontaneous abortion rate,

关 键 词：体外受精-胚胎移植 高凝状态 早期自然流产 

分 类 号：R711.6[医药卫生—妇产科学]