内异症患者血清和腹腔液中IL-17F与CA-125的临床意义  

Clinical significance of IL-17F and CA-125 in serum and peritoneal fluid detecting in endometriosis

作　　者：杨长群[1] 汪宏波[2] 金志珊[2] 刘妮英[1] 

机构地区：[1]湖北省新华医院妇产科,湖北武汉430015 [2]华中科技大学同济医学院附属协和医院妇科

出　　处：《中国妇幼保健》2013年第28期4725-4727,共3页Maternal and Child Health Care of China

基　　金：湖北省自然科学基金资助项目〔2012FFB02421〕

摘　　要：目的:探讨血清和腹腔液中IL-17F、CA-125水平的变化与子宫内膜异位症(EM)的关系。方法:收集确诊的EM患者29例为观察组,非EM患者26例为对照组,分析两组患者血清和腹腔液中的IL-17F和CA-125水平。结果:观察组血清、腹腔液中CA-125水平均明显高于对照组,差异有统计学意义(P<0.01),III^IV期血清、腹腔液中CA-125明显高于I^II期(P<0.05);I^II期腹腔液中IL-17F水平明显高于III^IV期(P<0.05)。观察组血清CA-125阳性率为69.0%,明显高于对照组的15.4%(P<0.01);腹腔液CA-125阳性率为89.7%,明显高于对照组的7.7%。腹腔液CA-125的灵敏度、特异度、准确度、阳性预测值、阴性预测值均高于血清CA-125。结论:腹腔液IL-17F可早期筛查EM,血清、腹腔液CA-125可中晚期筛查EM,腹腔液CA-125筛查效果好于血清CA-125。Objective： To explore the relationship between IL - I7F, CA - 125 level change in serum and peritoneal fluid and en- dometriosis （EM）. Methods ： 29 cases of EM patients were collected as case group, and 26 cases of non - EM patients as control group , the IL - 17F and CA - 125 levels in serum and peritoneal fluid were analyzed in the two groups. Results： CA - 125 level in serum and peri- toneal fluid of EM group were much higher than the control group, difference was statistically significant （P 〈 0.01 ） ; CA - 125 level in ser- um and peritoneal fluid of Ⅲ-Ⅳ stages were much higher than Ⅰ-Ⅱ stages （P 〈0. O1 ） ; IL - 17F level in peritoneal fluid ofⅠ-Ⅱ stages was much higher than Ⅲ-Ⅳstages （ P 〈 0. 05 ） . CA - 125 positive rate in serum of EM group was 69. 0% , much higher than the control group （ 15.4%, P 〈 0. 01 ） . CA - 125 positive rate in peritoneal fluid of EM group was 89.7% , much higher than the control group （7.7% , P 〈0. 01 ） . The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of CA - 125 in perito- neal fluid were all higher than CA - 125 in serum. Conclusion： IL - 17F in peritoneal fluid might early screen EM, and CA - 125 in serum and peritoneal fluid might screen EM in middle and advanced stages. Screening effect of CA -125 in peritoneal fluid is better than CA- 125

关 键 词：子宫内膜异位症 IL-17F CA-125 腹腔液 血清 

分 类 号：R711.71[医药卫生—妇产科学]