配伍对天麻中活性成分天麻苷元在大鼠体内分布的影响研究  

Study on effect of combined application on distribution of gastrodigenin in rats

作　　者：郑琴[1] 熊文海[1] 刘嘉宇[1] 王亚琴[1] 胡鹏翼[1] 胡双[1] 薛鑫[1] 杨明[1,2] 

机构地区：[1]江西中医学院现代中药制剂教育部重点实验室,江西南昌330004 [2]成都中医药大学,四川成都610075

出　　处：《中国中药杂志》2013年第19期3368-3372,共5页China Journal of Chinese Materia Medica

基　　金：江西省青年科学家培养计划项目(20122BCB23021);江西省卫生厅中医药科研计划项目(2010A091);江西省教育厅科学技术研究项目(GJJ13606)

摘　　要：该文采用高效液相色谱法测定各组织匀浆中天麻苷元的浓度,研究配伍前后天麻苷元在大鼠体内组织分布的变化,包括心、肝、脾、肺、肾、脑组织。研究表明天麻苷元在肾脏、肝脏、心脏、肺脏、脾脏、脑组织中均可分布,天麻、川芎配伍后,肝、肾中天麻苷元的含量不同程度的下降,肺、脑中含量上升,说明川芎对天麻活性成分天麻苷元的体内分布具有一定的影响,川芎能够促进天麻苷元向肺和脑组织分布。该文为天麻和川芎配伍治疗脑部疾病提供一定的科学依据。To determine the concentration of gastrodigenin in tissue homogenates with high performance liquid chromatography （ HPLC）, in order to study the changes of the distribution of gastrodigenin before and after combined application in rat tissues, inclu- ding heart, liver, spleen, lung, kidney and brain tissues. The study showed that gastrodigenin could be found in kidney, liver, heart, lungs, spleen and brain tissues. After the combined application of Gastrodiae Rhizoma and Ligustici Wallichii Rhizoma, the content of gastrodigenin decreased in kidney and liver to varying degrees, while increasing in lung and brain. This indicated that Ligustici Walli- chii Rhizoma had certain impact on the in vivo distribution of gastrodigenin, an active ingredient in Gastrodiae Rhizoma, because it could improve gastrodigenin＇s distribution in lung and brain tissues. The study provides scientific basis for the combined application of Gastrodiae Rhizoma and Ligustici Wallichii Rhizoma in treating brain diseases.

关 键 词：川芎 天麻 配伍 天麻苷元 组织分布 

分 类 号：R285.5[医药卫生—中药学]