补肾活血类中药治疗排卵障碍性不孕的系统评价  

Systematic evaluation of kidney-tonifying and blood-activating traditional Chinese medicines in treatment of ovulatory disorder infertility

作　　者：范晓迪[1] 马堃[1] 单婧[1] 金炫廷[1] 

机构地区：[1]中国中医科学院,北京100700

出　　处：《中国中药杂志》2013年第19期3382-3387,共6页China Journal of Chinese Materia Medica

基　　金：首都医学发展科研基金项目(SF-2009-I-02)

摘　　要：运用循证医学方法评价中医药治疗排卵障碍性不孕的临床研究。根据国际循证医学中心Cochrane协作网工作手册标准,制定补肾活血类中药治疗排卵障碍性不孕临床随机对照试验研究的选择标准。通过计算机在中文数据库、外文数据库检索符合标准的文献。对纳入的文献进行循证医学评价,并用Revman 5.1统计软件进行分析。有19篇文献符合标准,分别对妊娠率、排卵率、流产率进行数据提取及Meta分析三者异质性检验均无统计学异质性。妊娠率(n=17),RR P=1.66,95%Cl[1.45,1.92],Z=7.06(P<0.000 01);排卵率(n=11),RR O=1.05,95%Cl[0.97,1.12],Z=1.25(P=0.21);流产率(n=5),RR M=0.24,95%Cl[0.11,0.56],Z=3.33(P=0.000 9)。分析比较后发现中药治疗组妊娠率明显优于西药对照组,有统计学意义;2组排卵率无明显差别,无统计学意义;中药治疗组流产率明显低于西药对照组,有统计学意义。该研究初步探讨发现补肾活血类中药治疗排卵障碍性不孕较西药确有很好的的疗效与独特的优势。To evaluate clinical studies on effect of traditional Chinese medicines in treating ovulatory disorder infertility by using evidence-based medical method. According to the standard of Cochrane Handbook, the selection standard of the randomized con- trolled clinical trail on kidney-tonifying and blood-activating traditional Chinese medicines in the treatment of ovulatory disorder infertil- ity was formulated. Literatures in line with the standard were searched through computers among Chinese and English databases. The literatures included were evaluated by evidence-based medicine method, and analyzed with Revman 5. 1. There were 19 articles in line with the standard. Data for pregnancy rate, ovulation rate and miscarriage rate was extracted from them, and heterogeneity test was con- ducted with Meta, which showed no statistical heterogeneity. Results showed pregnancy rate （ n = 17）, RRp 1. 66, 95% C1 [ 1.45, 1.92], Z7.06 （P 〈0. 000 01） ; ovulation rate （n=ll）, RRo 1.05, 95% CI[0. 97,1.12], Z 1.25 （P=0.21） ; miscarriage rate （n =5）, RRM 0. 24, 95% CI[0. 11,0. 56], Z 3.33 （P =0. 000 9）. Mter analysis and comparison, it is found that the Chinese medi- cal treatment group was superior to the Western medicine control group in terms of pregnancy rate, which showed statistic signifi- cance. Both groups showed no obvious difference in the ovulation rate, and no statistic significance ; the miscarriage rate of the Chinese medicine group is obviously lower than that of the Western medicine control group, which indicated statistic significances. This study preliminarily proves the good efficacy and unique advantages of kidney-tonifyiug and blood-activating traditional Chinese medicines in treating ovulatory disorder infertility.

关 键 词：补肾活血 排卵障碍性不孕 系统评价 随机对照试验 

分 类 号：R271.14[医药卫生—中医妇科学]