阿托伐他汀钙片与脂必妥片早期治疗不稳定型心绞痛临床观察  

Clinical observation of atorvastatin calcium tablet and zhibituo tablet in early treatment of the patients with unsta-ble angina

作　　者：许玲 

机构地区：[1]河南省信阳市中心医院心内科,464000

出　　处：《中国实用医刊》2013年第20期36-37,共2页Chinese Journal of Practical Medicine

摘　　要：目的观察脂必妥片（0．35g／片）与阿托伐他汀钙片（10mg／片）早期治疗不稳定型心绞痛（UA）的降脂疗效、心功能改善情况、不良反应及对近中期心血管事件的影响。方法60例UA患者在给予抗血小板聚集、抗凝和抗缺血治疗的同时将其随机分成两组，脂必妥片组30例和阿托伐他汀钙组30例，分别于入院48h内开始口服脂必妥片1．05g，2次／d和阿托伐他汀钙10mg，1次／d，持续治疗至少8周，随访观察两组患者服药后12个月时血脂变化情况，并对临床事件做随访登记，同时观察用药安全性。结果脂必妥片与阿托伐他汀钙均能有效降低血脂总胆固醇（TC）及低密度脂蛋白胆固醇（LDL—C）水平，升高高密度脂蛋白胆固醇水平，对左室射血分数、左室舒张末内径和左室收缩朱内径（LVESD）的影响，后者明显优于前者。随访期间两组心肌梗死发生率、再住院率、心绞痛再发生率阿托伐他汀钙组较脂必妥组减少，差异有统计学意义（P〈0．05）。结论UA患者早期口服脂必妥片和阿托伐他汀钙均能降低血清TC及LDL—C水平，阿托伐他汀钙片疗效优于脂必妥片，且用药安全，不良反应小。Objective To investigate the effect and side effects of zhibituo tablet and atorvastatin calcium tablet on the early treatment of the patients with unstable angina（UA）. Methods Sixty cases of LIA were randomly divided into zhibituo tablet group and atorvastatin calcium tablet group, 30 cases in each group. Patients in zhibituo tablet group were o-rally given zhibituo tablet 1.05 g, 2 times/d, and patients in atorvastatin calcium tablet group were orally given atorvastatin calcium tablet 10 mg, 1 time/d for at least 8 weeks in each group. At the same time, all cases were continuously given an- tiplatelets, anticoagulants and antiischemia treatment. All cases were followed up and observed on the levels of TC, LDL-C and HDL-C in blood serum, clinic occurrences and medication rehabihties in 12 months. Results Both zhibituo tablet and atorvastatin calcium tablet could effectively decrease the levels of TC, LDL-C and raise the levels of HDL-C in blood ser- um, and variation of LVEF, LVEDD and LVESD. The effects of the latter were better than the former. There were signifi- cant differences between the two groups in the incidences of myocardial infarction, rehospitalization and cardic angina, ator- vastatin calcium table group was more superior to zhibituo table group. Conclusions Both of zhibituo tablet and atorvasta- tin calcium tablet can decrease the levels of TC and LDL-C in blood serum in patients with early period of UA. The effect of atorvastatin calcium tablet is better than that of zhibituo tablet, and has little side effect.

关 键 词：不稳定型心绞痛 阿托伐他汀钙片 脂必妥片 

分 类 号：R541.4[医药卫生—心血管疾病]