运动抗抑郁的神经生物学机制综述  

Research on the Neurobiological Mechanisms of the Antidepressant Effects of Physi cal Exercise

作　　者：齐红梅[1] 刘微娜[2,3] 季浏[2,3] 

机构地区：[1]南通大学体育科学学院,江苏南通226019 [2]青少年健康评价与运动干预教育部重点实验室,上海200241 [3]华东师范大学体育与健康学院,上海200241

出　　处：《首都体育学院学报》2013年第5期459-464,共6页Journal of Capital University of Physical Education and Sports

基　　金：国家自然科学基金项目(No.31200893);<青少年健康评价与运动干预>教育部重点实验室开放课题基金项目

摘　　要：近年研究表明,运动对抑郁有积极作用,其效果可媲美心理干预或药物治疗,甚至更为显著。而且适当运动无任何副作用,还能降低心血管疾病、糖尿病等的发病率。虽然运动作为抗抑郁的干预手段已引起了广泛关注,但其内在机制尚不明确。基于现有的抑郁症发病机理的各种假说,并结合运动抗抑郁的实证研究,提出运动抗抑郁的神经生物学机制可能涉及到中枢单胺类神经递质系统、神经营养物质、神经内分泌系统、神经免疫系统,以及中枢神经系统组织形态结构等方面的变化。这不仅进一步丰富运动抗抑郁机制的理论构架,而且为本领域的未来研究提供新视角。Researches in recent years show that physical exercise, as a non--pharmacological coping strategy, has been considered as effective as psychotherapy and even more effective than other pharmacological interventions with major depression. In addition,moderate exercise can reduce the incidence of cardiovascular disease and diabetes without any side effects. Effects of exercise in depression have attracted broad attention, yet the underlying mechanism is still unclear. Based on the pathological hypothesis on depres- sion, in combination with the empirical studies, the following factors are considered to explain the neurobi- ological effects of exercise in depression： central neurotransmitter, neurotrophic substance, neuroendocrine system,neuroimmune system,and morphological changes in central nervous system. It is supposed to enrich theoretical building and provide new perspectives for antidepressant effects of exercise.

关 键 词：抑郁 抗抑郁 运动 中枢神经系统 机制 

分 类 号：G804.8[文化科学—运动人体科学]