IL-33与人类疾病关系的研究进展  

Research progress on IL-33 and human diseases

作　　者：倪倩[1] 胡世莲[1] 尹辉[1] 

机构地区：[1]广东药学院病原生物学与免疫学系,广州510006

出　　处：《国际免疫学杂志》2013年第5期355-358,共4页International Journal of Immunology

基　　金：广东省自然科学基金（S2012010009409）;教育部留学回国人员基金（2011-1139）

摘　　要：IL-33是近年来发现的一种具有多种生物学功能活性的细胞因子,属于IL-1家族新成员,可作为核内定位分子发挥转录因子的作用,亦可作为一种前炎性细胞因子参与组织特异性免疫病理损伤.IL-33还被认为是细胞坏死后释放的一种“警报素”,在激发免疫系统引起组织损伤或反应中发挥重要作用.近年来证实,IL-33通过与其受体ST2结合,活化胞内核转录因子（NF）-κB等信号通路,参与调节炎症反应、感染性疾病、心血管疾病及肿瘤等多种疾病的发生发展过程.Interleukin （IL）-33,a new member of the IL-1 family of cytokines,has been found to exhibit a large body of biological activities.IL-33 may act as a nuclear localization factor and proinflammatory cytokine participating in specific immunopathological injuries in the meantime,IL-33 has also been identified as a new ‘alarmin＇ released when cell is damaged and plays a critical role in modulating tissue injuries or response.Recent studies suggest that activation of T1/ST2 receptor by IL-33 induces intracellular signaling through the NF-κB pathway as well as MAPKs.It has been demonstrated that IL-33 plays a critical role in various diseases such as inflammatory response,infectious diseases and cardiovascular diseases.In this review the role of IL-33 in the inflammation of several disease pathologies will be addressed.

关 键 词：IL-33 ST2 

分 类 号：R392.1[医药卫生—免疫学]