香蕉皮多酚对高脂血症大鼠血脂水平及抗氧化能力的影响  

Effect of Banana Peel Polyphenol on Blood Lipid and Antioxidant Capability in Hyperlipidemia Rats

作　　者：朱开梅[1] 赵文鹏[1] 赵磊[1] 骆彩珍[1] 顾生玖[1] 

机构地区：[1]桂林医学院药学院,广西桂林541004

出　　处：《中国实验方剂学杂志》2013年第19期213-216,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广西科技攻关专项(129825-21);广西教育厅项目(201202ZD065);桂林市科技攻关项目(20110106-5;20120105-5;20120105-16;20120105-8)

摘　　要：目的:以高脂血症大鼠为模型比较香蕉皮多酚、辛伐他汀降血脂及抗氧化作用。方法:60只大鼠随机分为6组,每组10只,即对照组、模型组、阳性药辛伐他汀组(10 mg·kg-1)、香蕉皮多酚低、中、高剂量组(30,60,120 mg·kg-1)。正常对照组喂食普通饲料,其余5组每天灌胃给予高脂饲料制备高脂血症大鼠模型,造模的同时给予香蕉皮多酚干预,连续给药40 d后测定总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、丙二醛(MDA)的含量,超氧化物歧化酶(SOD)的活性。结果:与正常对照组比较,模型组大鼠血清中TG,TC,LDL-C,MDA含量显著升高(P<0.05),而血清HDL-C,SOD,T-AOC活性显著降低(P<0.05);与模型组比较,香蕉皮多酚低、中、高剂量组大鼠血清TG,TC,LDL-C,MDA均有不同程度降低(P<0.05),血清HDL-C,SOD和T-AOC的活性显著升高(P<0.05)。结论:香蕉皮多酚对高脂血症模型大鼠具有降低血脂及抗氧化的双重作用。Objective： To compare the antihyperlipidemic and antioxidative effect of banana peel polyphenol and simvastatin. Method： Sixty rats were randomly divided into 6 groups, control group, model group, positive drug simvastatin group （10 mg·kg^-1）, banana peel polyphenol low, middle and high dose group, （30, 60, 120 mg·kg^-1 ） , 10 rats in each group. Control group were fed with common food, the remaining 5 groups were intragastrically given high fat diet, banana peel polyphenol was administrated at the same timefor 40 days. Then the content of cholesterol （TC） , triglyceride （TG） , high density lipoprotein-cholesterol （HDL-C） , low density lipoprotein-cholesterol （LDL-C）, malondialdehyde （MDA） and the activity of the super oxide dismutase （SOD） in serum were determined. Result： Compared with the normal control group, the rats in the model group, serum TG, TC, LDL-C, MDA were significantly increased （P 〈 0.05） , but the serum HDL-C, SOD, T-AOC activity was significantly decreased （P 〈 0.05） ; compared with the model group, the banana peel polyphenols of low, middle and high dose group, serum TG, TC, LDL-C, MDA were decreased in different degree （P 〈 0.05） , serum HDL-C, SOD and the activity of T-AOC increased significantly （P 〈 0. 05）. Conclusion： Banana peel polyphenol has antihyperlipidemic and antioxidative effects on hyperlipidemic model rats.

关 键 词：香蕉皮多酚 高脂血症 血脂水平 抗氧化 

分 类 号：R285.5[医药卫生—中药学]