复方阿胶浆对小鼠抗疲劳能力的影响  

Anti-fatigue Effect of Fufang Ejiao Jiang on Mice

作　　者：张路[1] 朱海芳[1] 陈慧慧[1] 张淹[1] 冯明建[1] 

机构地区：[1]国家胶类中药工程技术研究中心,山东东阿阿胶股份有限公司,山东聊城252201

出　　处：《中国实验方剂学杂志》2013年第19期254-257,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:探讨复方阿胶浆对运动小鼠抗疲劳能力的影响。方法:BALB/C纯系雄性小鼠60只随机分对照组、人参水提液组(10 g·kg-1)、复方阿胶浆低、中、高剂量组(7.5,15,30 g·kg-1)5组,灌胃30 d后,通过负重游泳实验,测定血乳酸(LA)、肝糖元、血红蛋白(Hb)、丙二醛(MDA)、乳酸脱氢酶(LDH)、血清肌酸激酶(CK)、血清尿素氮(BUN)的含量及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性。结果:与对照组比,复方阿胶浆低、中、高剂量组血LA、MDA的含量明显降低,血红蛋白的含量显著增加(P<0.05);中、高剂量组肝糖元、BUN的含量显著增加,CK的含量显著降低,GSH-Px的活性明显增强(P<0.05);中剂量组LDH的含量显著性降低(P<0.01),SOD的活性明显增强(P<0.05)。结论:复方阿胶浆可以有效延缓疲劳的产生、提高机体组织对疲劳的耐受力。Objective： To investigate anti-fatigue effect of Fufang Ejiao Jiang on mice. Mehtod： Sixty selected male mice were divided randomly into 5 groups： the control group, ginseng extract group （10 g ·kg^-1） and the low, medium, high dose Fufang Ejiao Jiang intervention groups （7.5, 15, 30 g·kg^-1 ）. Using the method of the weight loading swimming test, drugs were administrated to mice for 30 days. The contents of lactic acid （LA）, hepatic glycogen, haemoglobin （Hb）, malondialdehyde （MDA）, lactate dhydro-genase （LDH）, creatine kinase （ CK）, blood urea nitrogen （BUN） and the activities of glutathione peroxidase （ GSH-Px）, superoxide dismutase （SOD） in rats were dectected. Result： Compared with the control group, the low, medium and high dose groups after exercise, the content of LA, MDA was obviously reduced, the content of Hb was obviously increased （P 〈 0.05） ; the medium, high dose groups had a higher content of hepatic glycogen, BUN, a lower content of CK and a higher activity of GSH-Px （P 〈 0.05） ; the medium dose group had a lower content of LDH （P 〈0.01） and a higher activity of SOD （P 〈0.05）. Conclusion： Fufang Ejiao Jiang can be effective in delaying fatigue and improve tissue on fatigue resistance.

关 键 词：复方阿胶浆 抗疲劳 负重游泳 

分 类 号：R285.5[医药卫生—中药学]