蛇床子对运动训练大鼠睾酮含量、物质代谢及抗运动疲劳能力的影响  

Effect of Fructus cnidii on Testosterone Content,Substance Metabolism and Exercise Capacity in Rats Receiving Exercise Training

作　　者：邓艳香[1] 曹建民[2] 周海涛[3] 郑孟君[4] 

机构地区：[1]广西大学,南宁530004 [2]北京体育大学,北京100084 [3]北京联合大学生物化学工程学院,北京100023 [4]江南大学体育学院,江苏无锡214120

出　　处：《中国实验方剂学杂志》2013年第19期262-266,共5页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:研究蛇床子对运动训练大鼠睾酮含量、物质代谢及抗运动疲劳能力的影响。方法:以大强度耐力训练大鼠为模型,80只42 d龄雄性Wistar大鼠为对象,随机分为5组:静止对照组(C组)、运动对照组(T组)、运动+低剂量蛇床子组(TML组)、运动+中剂量蛇床子组(TMM组),运动+高剂量蛇床子组(TMH组)每组15只(剔除不符合实验要求的大鼠)。每天灌胃(ig)给药1次,蛇床子组剂量分别为0.75,1.5,4.5 g·kg-1,ig体积为5 mL·kg-1,静止对照组、运动对照组ig等量生理盐水。42 d力竭游泳训练后,测定体重、力竭游泳时间及血睾酮等生化指标。结果:蛇床子各剂量组体重大于运动组(P<0.05),力竭游泳时间长于运动组(P<0.01);血清睾酮高于运动对照组(P<0.01);血清皮质酮水平各组间均无显著差异,各组间血清睾酮与皮质酮比值变化与睾酮变化较为一致;肝糖原(P<0.05)、肌糖原(P<0.01)高于运动对照组;促卵泡激素无明显影响;血尿素低于运动对照组(P<0.05),血红蛋白高于运动对照组(P<0.05)。结论:蛇床子可以减轻血睾酮受高强度运动量的影响,并维持在正常生理水平;可以促进蛋白质合成,抑制氨基酸和蛋白质分解,提高运动训练大鼠血红蛋白含量和糖原的储备。Objective： To study the effects of Fructus cnidii on the content of testosterone, substance metabolism and anti-fatigue ability of rats. Method： By using the model of high-intensity endurance training, 80 male Wistar rats were divided into 5 groups, 15 in each group （the rats which did not meet the requirement were removed） ： control group （ C group）, motion control group （T group）, exercise ＋ ig low-dose F. cnidii group （TML group）, exercise ＋ ig middle-dose F. cnidii group （TMM group）, and exercise 4- ig high-dose F. cnidii group （TMH group）. Gavage was performed using professional device once a day. The rats in F. cnidii groups were treated with 0.75, 1.5,4.5 g ·kg^-1The rats in C and T groups were given saline of same volume. After 42 days of exhaustive swimming training, body weight, swimming time and serum testosterone and other biochemical markers were measured. Result： The body weight of the rats in F. cnidii groups increased compared with T group （ P 〈 0.05 ）, and the swimming time was longer than T group （P 〈 0.01 ）, serum corticosterone was lower than the T group （P 〈0.05 ）, changes in the ratio of serum testosterone/corticosterone were more consistent with testosterone changes among the groups. Liver glycogen （P 〈 0.05）, muscle glycogen （P 〈 0.01 ） and hemoglobin （ P 〈 0. 05） in F. cnidii group were higher than in T group, but the serum urea nitrogen was lower than the T group （P 〈 0.05）. Conclusion ： F. cnidii can alleviate the impact of high-intensity exercise on serum testosterone, and maintain it at normal physiological levels; it can also promote protein synthesis, inhibit degradation of amino acid and protein, and increase hemoglobin and glycogen reserves in rats exercise training.

关 键 词：蛇床子 睾酮 抗疲劳 

分 类 号：R285.5[医药卫生—中药学]