加味桂枝芍药知母汤治疗痛风性关节炎30例  

Observation for 30 Cases of Gouty Arthritis Treated with Modified Jiawei Guizhi Shaoyao Zhimu Decoction

作　　者：何晓红[1] 徐侦雄[1] 何羿婷[1] 

机构地区：[1]广东省中医院,广州510120

出　　处：《中国实验方剂学杂志》2013年第19期326-328,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(2012KT1472);广东省中医药管理局科技项目(101067)

摘　　要：目的:探讨加味桂枝芍药知母汤治疗痛风性关节炎的临床疗效。方法:将60例痛风患者随机按数字法分为治疗组和对照组,治疗组予加味桂枝芍药知母汤,对照组予塞来昔布胶囊口服,疗程均为1个月。观察治疗前后临床症状、体征的改善情况,检测实验室指标血尿酸(UA)、血沉(ESR)、C-反应蛋白(CRP)的变化。结果:治疗组总有效率(96.3%)优于对照组(76.6%)(P<0.05);两组治疗后疼痛、肿胀、活动受限积分均较治疗前有显著改善(P<0.01),并且治疗组优于对照组(P<0.05);两组治疗后实验室指标UA、ESR、CRP均较治疗前明显降低(P<0.01),治疗后治疗组UA水平低于对照组(P<0.05),ESR,CRP两组之间比较无统计学差异。结论:加味桂枝芍药知母汤治疗痛风性关节炎有较好的临床疗效,值得进一步研究与推广。Objective： This study is conducted to investigate the clinical efficacy of modified Jiawei Guizhi Shaoyao Zhimu decoction on gouty arthritis. Method： There were 60 patients with gouty arthritis and two groups of treatment and control were set up. Patients in the treatment group were treated with modified Jiawei Guizhi Shaoyao Zhimu decoction and patients in the control group were treated with celecoxib. The symptoms and biomarkers for gouty arthritis were examined after two weeks treatment. Result： The total effective rate is 93.3% and 90.0% in treatment and control group respectively. There was no statistical significance, though the symptoms of gouty arthritis in treatment group were improved much better than control group. The data obtained by experimental analysis from pre-and post-therapy were analyzed. There was significant difference for inter-group comparison （P 〈 0.05） , pain, swell, limitation of acvity, treatment group were much better than control group （P 〈 0.05）. and the reduction of blood uric acid in treatment group was dramatically significant as compared with control （P 〈0.01 ）. However, there was no any significant difference for the comparison of ESR and CRP between two groups. Conclusion： The modified Jiawei Guizhi Shaoyao Zhimu decoction has a significant clinical efficacy with the minimal side-effect.

关 键 词：加味桂枝芍药知母汤 痛风性关节炎 疗效观察 

分 类 号：R287[医药卫生—中药学]