超声波辐射下5-芳基-1,3,4-噁二唑-2-硫醚的合成及其抗菌活性研究  

Ultrasound irradiation-assisted synthesis and antibacterial activity of 5-aryl-1,3,4-oxadiazole-2-yl sulfanyl derivatives

作　　者：雷英杰[1] 刘淑颖[1] 毕野[1] 丁玫[1] 

机构地区：[1]天津理工大学化学化工学院,天津300384

出　　处：《化学试剂》2013年第9期827-829,850,共4页Chemical Reagents

摘　　要：为了研究具有1,3,4-二唑类结构物质的生物活性,利用芳酰肼与二硫化碳环合生成的5-芳基-1,3,4-二唑-2-硫酮为活性基团,超声波辐射聚乙二醇-400相转移催化条件下,探讨该中间体与氯乙酸乙酯或对甲基-N-氯乙酰基苯胺之间的烷基化反应,制备得到含有硫醚结构的5-芳基-1,3,4-二唑衍生物,其结构经IR、1HNMR和元素分析等测试技术加以确证;抗菌活性测试结果初步表明,目标产物具有一定的抗菌活性。In order to search for new bioactive substances containing 1, 3,4-oxadiazole, some of 5-aryl-1,3,4-oxadi- azole-2-ylsulfanyl derivatives were synthesized from the active intermediate 5-aryl-1,3,4-oxadiazole-2-thiones, which were prepared by the condensation of aromatic carboxylic acid hy- drazides with carbon disulfide and on subsequent acidifica- tion, with ethyl chloroacetate or 2-chloro-N-4-tolylaeetamidein alkaline media under ultrasound irradiation in the presence of PFG-400. The structures were confirmed by IR, 1HNMR spectra and elemental analysis. Preliminary bioassay results indicated that the title compounds had relatively antibacterial activity.

关 键 词：1 3 4-二唑 硫醚 超声波辐射 抗菌活性 

分 类 号：O626.2[理学—有机化学]