3-三氟乙氧基吡啶-2-磺酰胺的合成研究  

Synthesis of 3-(2,2,2-trifluoroethoxy) pyridine-2-sulfonamide

作　　者：方永勤[1] 张敏敏[1] 

机构地区：[1]常州大学设计研究院,江苏常州213164

出　　处：《化学试剂》2013年第9期853-856,共4页Chemical Reagents

摘　　要：以三氟乙醇和对甲苯磺酰氯为原料,通过亲核取代、Williamson醚化、巯基化、氧化、氨化5步反应制得标题化合物,着重对醚化、巯基化反应的工艺进行优化,产品纯度98%(HPLC)。中间体及目标产物经1HNMR确认。3-（ 2,2,2-Trifiuoroethoxy ） pyridine-2-sulfonamide was prepared with trifluoroethanol and tosyl chloride via the nucleophilicsubstitution, Williamsonetherification, thiolated, oxidation and ammoniated. The effects of the reaction condi- tion of etherification and thiolated on the yields were investi- gated. The purity of target product was 98% （HPLC）. A]I compounds obtained were identified by 1HNMR.

关 键 词：3-三氟乙氧基吡啶-2-磺酰胺 2-氯-3-羟基吡啶 三氟啶磺隆 醚化 巯基化 

分 类 号：TQ457.2[化学工程—农药化工]