基于倾向评分法探讨灯盏细辛注射液对冠心病结局的影响  

Explore Dengzhan Xixin injection effecting on outcome of coronary heart disease based on propensity score

作　　者：卢鹏飞[1] 曾宪斌[2] 谢雁鸣[1] 杨伟[1] 黎元元[1] 杨薇[1] 王志国[1] 

机构地区：[1]中国中医科学院中医临床基础医学研究所,北京100700 [2]中国人民大学统计学院,北京100872

出　　处：《中国中药杂志》2013年第18期3121-3128,共8页China Journal of Chinese Materia Medica

基　　金：国家"重大新药创制"科技重大专项(2009ZX09502-030);国家自然科学基金青年基金项目(81173472);中国中医科学院第7批自主选题项目(Z0255)

摘　　要：该研究从全国20家三甲综合医院信息管理系统(hospital information system,HIS)中提取数据,共获得2 325例诊断为"冠心病"的患者住院信息,其中768例为使用灯盏细辛患者,1 557例为未使用灯盏细辛患者。该文基于倾向评分法,平衡大量混杂因素的影响,同时应用3种Logistic回归方法对比分析冠心病的治愈率。结果显示2组之间已知的72个混杂因素,如:年龄、入院病情、病危天数等,3种Logistic回归方法回归系数均为负值,且检验P<0.05,从统计学意义上讲,使用灯盏细辛注射液对冠心病的治愈率显著高于未使用灯盏细辛注射液。由于该研究是应用回顾性分析方法,且倾向性评分方法无法对未知混杂因素进行分析,因此所分析结果有一定局限性。Records of 2 325 patients with CHD were extracted from 20 hostpial information systems, who were divided into two groups, one group has 768 patients using Dengzhan Xixin, the other group has 1 557 patients without using Dengzhan Xixin. Using generalized boosted models （GBM） with propensity scores to balance confounding factors and using three Logistic regressions to analy- sis the cure rates of coronary heart disease. The results is that 72 knowing confounding factors between two groups, such as ： age, ad- mission condition, dying days, regression coefficients of three Logistic regressions were negative（ P 〈 0.05 ）, statistically, the result of using Dengzhan Xixin injection to cure coronary heart disease is significantly higher than do not using Dengzhan Xixin injection. Pro- pensity score could be a good method to balance confounding factors in a retrospective data analysis. However it is not a prospective re- search, the information from this study should be carefully referred to.

关 键 词：倾向评分 灯盏细辛注射液 冠心病 真实世界 治愈率 

分 类 号：R259[医药卫生—中西医结合]