氧化石墨催化醇和酚的四氢吡喃化保护与脱保护  

Graphite Oxide as an Efficient and Reusable Catalyst for Tetrahydropyranylation/Depyranylation of Alcohols and Phenols

作　　者：徐亮[1] 杨安卫[1] 马宁[1] 

机构地区：[1]天津大学理学院化学系,天津300072

出　　处：《有机化学》2013年第9期2004-2009,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20802049)资助项目~~

摘　　要：氧化石墨作为一种高效、低毒、易得、可重复使用的弱酸性催化剂用于醇和酚的四氢吡喃化保护与脱保护反应.反应在室温下短时间内即可完成,产物收率高,分子中的碳碳不饱和键不受影响,氧化石墨可重复使用至少4次.该方法具有操作简便、安全、经济、环境友好等优点.Graphite oxide serves as an efficient, lowly toxic, easily available, weakly acidic and reusable catalyst for tetrahydropyranyl protection and deprotection of alcohols and phenols. Various alcohols and phenols, including the unsaturated ones, were steadily tetrahydropyranylated and subsequently depyranylated into the corresponding products at room temperature during short reaction time in good to quantitative yields. Graphite oxide could be reused at least four times. This method is convenient, safe, economical and environmentally benign.

关 键 词：氧化石墨 催化剂 四氢吡喃化 醇 酚 

分 类 号：O643.32[理学—物理化学]