紫外分光光度法测定甲磺酸罗哌卡因注射液的含量  

Content Determination of Ropivacaine Mesylate Injection by UV Spectrophotometry

作　　者：雷晓雪[1] 陶元景[1] 陈文芝[1] 王丽楠[1] 

机构地区：[1]扬子江药业集团南京海陵药业有限公司,南京210049

出　　处：《中国药房》2013年第37期3540-3541,共2页China Pharmacy

摘　　要：目的：建立快速测定甲磺酸罗哌卡因注射液生产中中间产品含量的方法。方法：采用紫外分光光度法。以0.9%氯化钠溶液为溶剂,检测波长为262 nm,同时与高效液相色谱法含量测定结果比较。结果：甲磺酸罗哌卡因检测质量浓度线性范围为37~740μg/m（lr=0.999 8）,平均回收率为99.80%（RSD=0.4%,n=9）。2种方法含量测定结果一致。结论：建立的方法简便、准确、快速,可用于甲磺酸罗哌卡因注射液大生产过程中中间产品的质量控制。OBJECTIVE： To establish a rapid method for the content determination of intermediate product of Ropivacaine me- sylate injection. METHODS： UV spectrophotometry was adopted. 0.9 % sodium chloride solution was taken as solvent and the de- tection wavelength was set at 262 nm. Result of the method was compared with that of HPLC method. RESULTS： The linear range of ropivacaine mesylate were 37-740 pg/ml （r----0.999 8） with an average recovery of 99.80% （RSD=0.4%, n=9）. Results of content determination by 2 kinds of methods were the same to each other. CONCLUSIONS： Established method is simple, accurate and rapid, and it can be used for quality control of intermediate product of Ropivacaine mesylate injection.

关 键 词：紫外分光光度法 甲磺酸罗哌卡因注射液 含量测定 

分 类 号：R927.2[医药卫生—药学]