苦参碱脂质体的稳定性及体外释放度研究  

Study on Stability and Release Rate in vitro of Matrine Liposome

作　　者：仵文英[1] 李莎[2] 徐晓娜[2] 李兴华[1] 马小亚[1] 

机构地区：[1]西安交通大学医学院第二附属医院药剂科,西安710004 [2]西安交通大学医学院药学系,西安710061

出　　处：《中国药房》2013年第37期3542-3544,共3页China Pharmacy

摘　　要：目的:考察苦参碱脂质体的稳定性及体外释放度。方法:用硫酸铵梯度法制备苦参碱脂质体,考察其粒径、形态和包封率;以渗漏率为指标考察苦参碱脂质体在4℃和室温放置9个月内的稳定性;同时采用桨碟法考察苦参碱脂质体的体外释放情况。结果:制备的苦参碱脂质体的平均粒径为220 nm,包封率为63.37%,4℃放置9个月的渗漏率为(10.7±0.1)%。脂质体的体外释放规律符合Higuchi方程。结论:苦参碱脂质体应在冷藏条件下贮存,其在体外具有良好的缓释作用。OBJECTIVE： To study the stability and release rate in vitro of Matrine liposome. METHODS： The ammonium sul- fate gradient method was applied to produce the liposome, and the diameter, morphology and entrapment efficiency were studied. Using leakage rate as index, the stability of Matrine liposome at 4 ℃ and room temperature was investigated within 9 months, and the release behavior of the drug was studied by paddle over disk method. RESULTS： The average particle size of Matrine liposome was 220 nm and entrapment efficiency was 63.37%; the leakage rate of drug was （10.7 _＋ 0.1）% at 4 ℃ within 9 months. The re- lease rule in vitro was up to the Higuchi equation. CONCLUSIONS： Matrine liposome should be kept in cold storage and has sus- tained-release effect.

关 键 词：苦参碱脂质体 稳定性 渗漏率 体外释放度 

分 类 号：R927.2[医药卫生—药学]