化疗对恶性肿瘤患者血液流变学影响的研究  

Study on the influence of chemotherapy on the hemarheology of the patients with cancer

作　　者：夏春芳[1] 左玉兰[1] 马丽丽[2] 杨群[1] 赵丽萍[1] 

机构地区：[1]中南大学湘雅二医院,湖南长沙410011 [2]中南大学护理学院,湖南长沙410013

出　　处：《中国现代医学杂志》2013年第23期94-97,共4页China Journal of Modern Medicine

基　　金：湖南省科技厅资助项目(No:2010SK3107)

摘　　要：目的探讨化疗对恶性肿瘤患者血液流变学的影响。方法选取2011年7月~2012年2月入住该院的86例恶性肿瘤初治患者,其中血液系统肿瘤患者50例患者,胃肠道肿瘤患者36例。上述患者于化疗前及化疗4个周期后,分别检测其外周血的血液流变学情况。比较化疗前后血液流变学指标的变化趋势。结果胃肠道肿瘤患者化疗后血液流变学各指标中,全血黏度值（切变率为1、5、50、100、200）、全血高切相对指数、全血低切还原黏度、全血高切还原黏度及红细胞刚性指数均较化疗前降低,差异有统计学意义（P〈0.05）;血液系统肿瘤患者化疗后血液流变学各指标中,全血黏度值（切变率为1、5、50、100、200）、血浆黏度、红细胞压积、全血低切相对指数、红细胞聚集指数、全血低切还原黏度、全血高切还原黏度及红细胞刚性指数均较化疗前升高,差异有统计学意义（P〈0.05）。其余指标化疗前后差异无统计学意义（P〉0.05）。结论化疗后胃肠道肿瘤患者血液流变学指标降低,有趋向正常的趋势,而血液系统肿瘤患者血液流变学指标有升高的趋势。【Objective】 To explore the influence of chemotherapy on the hemarheology of the patients with cancer.【Methods】 Totally 86 patients with cancer all who were first treated were selected in our research.50 patients with hematological malignancy,36 patients were with gastrointestinal cancer.The hemodynamic indexes of all the 86 patients were tested before and after 4 cycles of chemotherapy.【Results】 The means of the whole blood viscosity,the whole blood relative viscosity,the whole blood reduced viscosity,the whole blood high cut reduction viscosity and erythrocyte rigidity index after 4 cycles chemotherapy of the patients with gastrointestinal cancer were lower than the means of the indexes before chemotherapy.The differences have obvious statistical significance（P 0.05）.The means of the whole blood viscosity,the plasma viscosity,the hematocrit,the whole blood low cut relative viscosity,the red blood cell aggregation,the whole blood reduced viscosity,the whole blood high cut reduction viscosity and erythrocyte rigidity index after 4 cycles chemotherapy of the patients with hematological malignancy were higher than the means of the indexes before chemotherapy.The differences had obvious statistical significance（P 0.05）.The others had no statistical significance（P 0.05）.【Conclusion】 The hemarheology indexes of the patients with gastrointestinal cancer have an increasing trend after chemotherapy,while the hemarheology indexes of the patients with hematological malignancy have a decreasing trend.

关 键 词：血液流变学 化疗 恶性肿瘤 

分 类 号：R446.112[医药卫生—诊断学]