蚊虫气味结合蛋白的研究进展  

Research progress of ordorant binding proteins of mosquitoes

作　　者：代玉华[1,2] 史世俊[1] 刘丽娟[1] 王海防[1] 程鹏[1] 公茂庆[1] 

机构地区：[1]山东省寄生虫病防治研究所,山东济宁272033 [2]河南出入境检验检疫局,河南郑州450003

出　　处：《中华卫生杀虫药械》2013年第5期449-452,共4页Chinese Journal of Hygienic Insecticides and Equipments

基　　金：国家自然科学基金资助项目(编号:81201317;81201318);山东省优秀中青年科学家科研奖励基金(编号:bs2011SW032)

摘　　要：蚊虫是我国重要的媒介昆虫,可以传播疟疾、登革热、黄热病等多种疾病。蚊虫的许多行为要依赖嗅觉系统,包括寄主搜寻、产卵以及糖源搜寻等。气味结合蛋白是帮助气味小分子到达受体的载体,也是近年来研究蚊虫嗅觉系统的热点之一。现将蚊虫气味结合蛋白的结构、功能、分子机制以及遗传进化等作一综述。Mosquitoes are one of the most important vectors in China. They are known to have transmitted diseases such as malaria, yellow fever, West Nile Virus. Olfaction system plays crucial role in mosquito host seeking, oviposition and searching for sugar sources. Odorant-binding proteins （OBPs） are involved in the first step of odorant reception where they bind, solubilize and deliver odorant melecules to olfactory receptors. This paper summarizes the lately re- search progress of OBPs, including the characteristics of structure, physiological function, molecular mechanism and evolution.

关 键 词：蚊虫 嗅觉系统 气味结合蛋白 

分 类 号：R384.1[医药卫生—医学寄生虫学]