Effect of nanopore size on poly(dT)_(30) translocation through silicon nitride membrane  

作　　者：SI Wei SHA JingJie LIU Lei QIU YingHua CHEN YunFei 

机构地区：[1]Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, Southeast University

出　　处：《Science China(Technological Sciences)》2013年第10期2398-2402,共5页中国科学（技术科学英文版）

基　　金：supported by the National Basic Research Program of China(Grant No.2011CB707605);the Natural Science Foundation of China(Grants Nos.50925519,51003015,and 51005048);the Research Funding for the Doctor Program from China Educational Ministry(Grant No.20100092110051)

摘　　要：The nanopore size effect on translocation of poly(dT)30through Si3N4 membrane is investigated.In this paper,we report that the speed of the poly(dT)30 transport through Si3N4 nanopores can be slowed down by half through increasing the nanopore diameter from 4.8 nm to 10.8 nm.The results are consistent with our simulation results.Besides,the current blockage induced by DNA passing through the nanopore is less obvious as pore diameter is larger,which is in good agreement with the theoretical prediction.The conclusion about DNA transport through nanopores is beneficial for the design of DNA sequencing devices.

关 键 词：solid-state nanopore nanopore technology single molecule sensor molecular dynamics simulation slow down 

分 类 号：TB383.1[一般工业技术—材料科学与工程]