Long non-coding RNA-guided regulation in organisms  

作　　者：QI WenChuan SONG Xu LI Ling 

机构地区：[1]Center for Functional Genomics and Bioinformatics,Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education,College of Life Science,Sichuan University [2]State Key Laboratory of Biotherapy,West China Hospital,Sichuan University

出　　处：《Science China(Life Sciences)》2013年第10期891-896,共6页中国科学（生命科学英文版）

基　　金：supported by grants from the National Basic Research Program of China(2011CB504203);National Natural Science Foundation of China(31000579,31371325);Innovative Research Team Program of Sichuan Province(2011JTD0026);the Program for New Century Excellent Talents in the University of Ministry of Education of China(NCET-10-0599)

摘　　要：It is clear that RNA is more than just a messenger between gene and protein.The mammalian genome is pervasively transcribed,giving rise to tens of thousands of non-coding transcripts.Whether all of these transcripts are functional remains to be elucidated,but it is evident that there are many functional long non-coding RNAs(lncRNAs).Recent studies have set out to decode the regulatory role and functional diversity of lncRNAs.Here we organize these studies to highlight the significant involvements of lncRNAs in regulation of gene expression and human physiological and pathological processes,which are achieved by their interaction with DNA,RNA or protein.It is clear that RNA is more than just a messenger between gene and protein. The mammalian genome is pervasively tran- scribed, giving rise to tens of thousands of non-coding transcripts. Whether all of these transcripts are functional remains to be elucidated, but it is evident that there are many functional long non-coding RNAs （lncRNAs）. Recent studies have set out to decode the regulatory role and functional diversity of lncRNAs. Here we organize these studies to highlight the significant in- volvements of lncRNAs in regulation of gene expression and human physiological and pathological processes, which are achieved by their interaction with DNA, RNA or protein.

关 键 词：lncRNAs gene expression physiological and pathological processes interaction 

分 类 号：Q522[生物学—生物化学] Q19