布洛芬原位凝胶体外溶蚀和药物释放度考察  

Study of in vitro dissolution and drug release for ibuprofen in-situ gel

作　　者：麻纪斌 曲秦 董凯[2] 翟帆[1] 李宗霖[1] 陈雁 邢建峰[2] 

机构地区：[1]陕西新药技术开发中心,西安710075 [2]西安交通大学药学院,西安710061 [3]西安市第五医院,西安710082

出　　处：《西北药学杂志》2013年第5期513-514,共2页Northwest Pharmaceutical Journal

基　　金：陕西省科学技术研究发展计划项目(编号:2009k19-03);陕西省创新能力建设项目--陕药集团技术中心.原位凝胶制剂研究(2010)

摘　　要：目的对布洛芬原位凝胶剂进行体外溶蚀和释放度考察,探索处方中布洛芬与PVP K30的最佳比例。方法采用无膜溶出法,根据公式凝胶累积溶蚀百分率=(W1-Wt)/(W1-W0)来计算溶蚀率;根据标准曲线,利用峰面积计算药物累积释放率。结果当布洛芬∶PVP K30=1∶1时,制成的凝胶的性质最好。随着时间的递增,凝胶的溶蚀率和释放率显著增加。结论布洛芬凝胶剂具有良好的缓释效果。Objective The erosion and dissolution for in-situibuprofen was studied in order to optimize the ratio of ibuprofen and PVP K30 in the prescription.Method The membrane-free method was used.The erosion rate was calculated according to the formula,cumulative erosion percentage=（W1-Wt）/（W1-W0）.The drug cumulative release rate was calculated by using the peak area according to the standard curve.Results When the proportion of ibuprofen and PVP K30 was 1∶1,the ratio of erosion and release increased significantly with the increase of time.Conclusion The in situibuprofen gels showed excellent sustained release characteristics.

关 键 词：布洛芬 原位凝胶 溶蚀率 释放度 

分 类 号：R944[医药卫生—药剂学]