自拟中药浴足方治疗早期糖尿病足临床研究  

Clinical Study on Early Diabetic Foot Treated by Self-made Chinese Medicine Yuzu Prescription

作　　者：郭家安 王红燕 

机构地区：[1]广水市第一人民医院,湖北广水432700

出　　处：《中医学报》2013年第10期1543-1545,共3页Acta Chinese Medicine

基　　金：国家自然科学基金项目(编号:03860285)

摘　　要：目的:探讨自拟中药浴足方治疗早期糖尿病足的临床疗效。方法:将64例早期糖尿病足患者按照抽签法随机地均分为对照组与观察组,各32例。对照组给予常规的西医治疗,观察组在此基础上给予自拟中药浴足方治疗,比较两组临床疗效及治疗前后中医临床证候积分、踝臂血压指数、肢体位置阳性率、空腹血糖(FBG)、餐后2 h血糖(PBG)、糖化血红蛋白(HbAlc)、胆固醇(TC)、三酰甘油(TG)等变化情况。结果:①对照组治疗有效率为65.63%,明显低于观察组(93.75%)(P<0.01);②两组治疗前后中医临床证候积分差异均具有统计学意义(P<0.05,P<0.01),且观察组治疗后第8周中医临床证候积分与对照组治疗后第8周比较,差异具有统计学意义(P<0.05),但是两组治疗后第12周中医临床证候积分比较无统计学差异(P>0.05);③观察组踝臂血压指数、肢体位置阳性率均明显大于对照组(P<0.05);④对照组治疗前后FBG、PBG、HbAlc、TC及TG变化无统计学差异,但观察组治疗前后上述指标比较,差异均具有统计学意义(P<0.05,P<0.01),且治疗后观察组上述指标与对照组比较,差异均具有统计学意义(P<0.05)。结论:自拟中药浴足方治疗早期糖尿病足疗效显著。Objective：To investigate the clinical effect of self-made Chinese medicine Yuzu Prescription treatment of patients with early diabetic foot. Methods ：64 cases of patients with early diabetic foot were divided into the control group and the observation group by sor- tition randomization method, each of 32 cases. The control group was treated with western medicine, and the observation group was given Chinese medicine treatment on basis of the control group. And the clinical efficacy, Chinese medicine clinical symptom scores, and an- kle-brachial blood pressure index, body position positive rate, fasting blood glucose （FBG） ,2 h postprandial blood glucose （PBG）, gly- cosylated hemoglobin （ HbA1 c）, total cholesterol （TC）, triglyceride （TG） changes were compared before and after treatment. Results： ①The effective rate was 65.63% in the control group, which was significantly lower than the observation group （93.75%） （P 〈 0. 01 ）.②There were statistical difference of the clinical syndrome scores in the two groups before and after treatment（ P 〈 0.05, P 〈 0. 01 ） ,and 8 weeks after treatment, comparison of TCM clinical syndrome integral between the two groups showed that the difference was statistically significant（P 〈0.05 ）, but 12 weeks after treatment, comparison of TCM clinical syndrome integral between the two groups showed that there was no significant difference（P 〉0.05）. ③The ankle-brachial blood pressure index, the physical location of the positive rate in the observation were both significantly larger than that in the control group （P 〈 0.05 ）.④There was no statistical difference of FBG, PBG, HbA1 c, TC and TG change in the control group before and after treatment, but there was a statistical difference of these indicators in the observation group before and after treatment （ P 〈 0.05, P 〈 0.01 ）, and there was a statistical difference be- tween the two group after treatment （ P 〈 0.05 ）. Conclusion ： Self-made Chinese medici

关 键 词：糖尿病 早期糖尿病足 中药浴足方 

分 类 号：R259.871[医药卫生—中西医结合]