他汀类药物与甲状腺疾病  

Statins and thyroid diseases

作　　者：陈鹏[1] 徐书杭[1] 陈国芳[1] 刘超[1] 

机构地区：[1]南京中医药大学附属中西医结合医院内分泌代谢病院区,210028

出　　处：《国际内分泌代谢杂志》2013年第5期308-310,313,共4页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（81200577）

摘　　要：甲状腺疾病如甲状腺癌、甲状腺结节在全球范围内的发病率和患病率逐年升高.他汀类药物抑制胆固醇合成的同时,抑制甲羟戊酸及其下游产物,阻断了与肿瘤增殖、新生血管形成及肿瘤转移相关信号通路,进而发挥抑制肿瘤细胞生长的作用.此外,他汀类药物还可减少甲状腺结节的体积及患病率,通过免疫调节作用改善桥本甲状腺炎患者的甲状腺功能,并能对甲状腺相关眼病的进展起到缓解作用.The incidence and prevalence of thyroid diseases such as thyroid cancer and thyroid nodule are increasing worldwide.By blocking mevalonate and related downstream pathways,statins inhibit proliferation,angiogenesis and metastasis of cancer cells as well as cholesterol production,finally lead to growth inhibition of cancer cells.Furthermore,statins reduce the volume of thyroid nodule and its prevalence,and improve thyroid function in patients with Hashimoto＇s thyroiditis through immunomodulation.Meanwhile,statins can delay the progression of thyroid associated ophthalmopathy.

关 键 词：他汀类药物 甲状腺癌 甲状腺结节 桥本甲状腺炎 甲状腺相关眼病 

分 类 号：R581[医药卫生—内分泌]