冷暴露对下丘脑能量平衡基因表达的影响  

Influence of cold exposure in energy balance related gene expression in hypothalamus

作　　者：乔小娜[1] 赵苇苇[1] 杨叶虹[1] 

机构地区：[1]复旦大学附属华山医院内分泌科,上海200040

出　　处：《国际内分泌代谢杂志》2013年第5期321-324,共4页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（81000329）

摘　　要：下丘脑是机体能量平衡的调节中枢.冷暴露下,下丘脑内能量平衡相关激素的表达水平将发生变化,主要包括促甲状腺激素释放激素、促肾上腺皮质激素释放激素、瘦素、神经肽Y/刺鼠相关蛋白、前阿片黑素细胞皮质激素/可卡因-苯丙胺转录调节肽、N-甲基-D-天冬氨酸受体及脑源性神经营养因子.这些激素通过复杂的神经内分泌网络,改变机体的摄食和产热,从而调控机体的能量平衡.因此,研究冷暴露对下丘脑能量平衡基因表达的影响将为肥胖等代谢紊乱性疾病的治疗提供新思路.Hypothalamus is the center of energy balance in the body.While the body is exposed to the cold conditions,the expression of energy balance related hormones will be modulated in hypothalamus,including thyrotropin releasing homone,corticotrophin releasing hormone,leptin,neuropeptide Y/agouti-related protein,proopiomelanocortin/cocaine alanine transcriptional regulation peptide,N-methyl-d-aspartate and brain-derived neurotrophic factor.These hormones change the food intake and thermogenesis through complex neuroendocrine network so as to control the energy balance.Therefore,studing the role of cold exposure in regulation of energy balance related gene expression in hypothalamus would provide new ideas in the treatment of obesity and other metabolic disorders.

关 键 词：冷暴露 下丘脑 能量平衡 

分 类 号：R589.2[医药卫生—内分泌]