脂肪肾素-血管紧张素-醛固酮系统与肥胖及其相关疾病  

Adipose rennin-angiotensin-aldosterone system in obesity and its related disease

作　　者：曾惠娴[1] 孙嘉[1] 

机构地区：[1]南方医科大学珠江医院内分泌科,广州510282

出　　处：《国际内分泌代谢杂志》2013年第5期329-331,共3页International Journal of Endocrinology and Metabolism

摘　　要：脂肪肾素-血管紧张素-醛固酮系统（RAAS）主要存在于白色脂肪组织,表达RAAS的所有成分,具有独立调节功能.游离脂肪酸增多可使脂肪RAAS过度激活,脂肪RAAS中活性成分血管紧张素Ⅱ及醛固酮可导致脂肪细胞异常分化、脂代谢异常、胰岛素敏感性下降、炎性反应加重,从而参与肥胖及其相关疾病的发生、发展.下调过度激活的脂肪RAAS可能是治疗肥胖及其相关代谢性和炎性反应性疾病的新靶点.Adipose rennin-angiotensin-aldosterone system （RAAS） mainly located in the white adipose tissue,it expresses all the ingredients of RAAS and takes autonomic regulation.The increase of free fatty acids may trigger the inappropriate activation of adipose RAAS.As the active ingredients of adipose RAAS,angiotensin Ⅱ and aldosterone result in the abnormal adipocyte differentiation,abnormal lipid metabolism,declining insulin sensitivity and increasing inflammation so as to play roles in the occurrence and development of obesity and its related diseases.Interference with inappropriate activation of adipose RAAS may be a new therapeutic target for obesity and its related metabolic and inflammatory disease.

关 键 词：脂肪肾素-血管紧张素-醛固酮系统 肥胖 血管紧张素Ⅱ 醛固酮 

分 类 号：R589.2[医药卫生—内分泌]