阿霉素纳米粒在小鼠体内释放的模型拟合  

A study on model fitting of the vivo release of PVP-ADM-NP in mice

作　　者：吕凤娇[1] 谢晓兰[1] 许小平[2] 

机构地区：[1]泉州师范学院分子生物与药物化学福建省高校重点实验室,福建泉州362000 [2]福州大学化学化工学院,福建福州350002

出　　处：《计算机与应用化学》2013年第9期1047-1050,共4页Computers and Applied Chemistry

基　　金：福建省教育厅A类科技项目(JA11223);泉州师范学院2012年校级自选项目(2012KJ13);泉州师范学院重点学科建设项目资助(MDSCh-2009A)

摘　　要：目的:对阿霉素纳米粒在小鼠体内的释放行为进行模型拟合。方法:以昆明小鼠为研究对象,采用静脉注射给药,用HPLC-荧光检测法测定阿霉素溶液和阿霉素纳米粒2种剂型下小鼠血药浓度的变化,比较两种剂型下阿霉素在小鼠体内药时浓度的变化情况,并采用模型对其进行拟合预测。结果:在给定同样剂量条件下,阿霉素溶液刚开始时获得较高血药浓度,但血药浓度降低较快,在24 h时血药浓度已经很低,而阿霉素纳米粒在体内的消除较慢,在24 h依然保持一定浓度。阿霉素纳米粒组和阿霉素溶液组血药浓度曲线均用二室模型拟合较好。结论:阿霉素纳米粒分布和消除都较为缓慢,有一定的缓释效果。Model fitting of the vivo release of PVP-ADM-NP in mice was explored. METHODS In vivo experiment of NP, HPLC-FLD was utilized for the determination of ADM contention in blood plasma. NP and ADM solution were injected into the veins of rats by the same dose. One-compartment model and Two-compartment model were used to fit the blood plasma under NP and ADM solution. RESULTS The results showed that Two-compartment model could fit better than One-compartment model both the NP and ADM solution. CONCLUSION Compare with ADM solution, distribution and elimination of the ADM-NP was relatively slow, and showed a certain slow release.

关 键 词：阿霉素 纳米粒 体内释放 模型拟合 

分 类 号：TQ46[化学工程—制药化工] TP206.3[自动化与计算机技术—检测技术与自动化装置]