一种轴向核苷修饰硅酞菁的合成与光动力抗癌活性  

Synthesis and Photodynamic Anticancer Activity of Silicon Phthalocyanine Axially Modified by Nucleoside Derivatives

作　　者：沈小敏[1] 郑碧远[1] 张汉辉[1] 黄剑东[1] 

机构地区：[1]福州大学化学化工学院,福建福州350108

出　　处：《光谱学与光谱分析》2013年第10期2731-2735,共5页Spectroscopy and Spectral Analysis

基　　金：国家自然科学基金项目(21172037);福建省自然科学基金项目(2011J01040);高等学校博士学科点专项科研基金项目(20113514110001)资助

摘　　要：合成了一种轴向核苷修饰硅酞菁,即二[5′-(2′,3′-O-异丙基)-5-甲基胞苷氧基]硅酞菁,并通过1 H NMR和HR-MS等手段进行了表征。该化合物在N,N-二甲基甲酰胺和含1%Cremophor EL水溶液中以单体形式存在,Q带最大吸收波长分别位于676和679nm,荧光发射峰分别位于685和689nm。离体光动力抗癌活性表明,该化合物具有显著的光动力抗癌活性,对人肝癌细胞HepG2的半致死浓度(IC50)低至7.8×10-8 mol·L-1。荧光共聚焦显微镜研究显示,SiPcG可定位于细胞线粒体中。研究表明,SiPcG是一种有发展潜力的新型抗癌光敏剂。A new axially modified silicon phthalocyanine, di [-5＇-（2＇, 3 ＇-O-isopropyl）-5-methyl cytidineoxy] silicon phthalocya- nine （SiPcG）, was prepared and characterized By 1H NMR and HRMS. This compound is essentially nonaggregated in N, N- dimethyformamide and 1 % cremophor EL aqueous solution. It shows a Q-band at 676 nm and fluorescence emission at 685 nm in DMF, and exhibits a Q-band at 679 nm and fluorescence emission at 689 nm in 1% cremophor EL aqueous solution. The SiPcG shows a high photodynamic activity against human hepatoma cells HepG2 with an IC50 value down to 7. 8×0-8mol . L-1. Fluo- rescence confocal microscopy study indicated that the SiPcG locates preferentially in the mitochondria of cells. The research re- sults show that the SiPcG is highly potential as a new anti-cancer photosensitizer.

关 键 词：硅酞菁 核苷 合成 光动力抗癌活性 

分 类 号：O644[理学—物理化学]