壳聚糖修饰金属卟啉的制备及磁共振成像性能  

Preparation of and Study on Magnetic Resonance Imaging Performance of Metal Porphyrin Modified by Low Molecular Weight Chitosan

作　　者：俞东军[1] 李敏智[1] 黄显著[1] 朱卫华[1] 黄燕[1] 张岐[1,2] 刘清[1] 

机构地区：[1]江苏大学化学化工学院,江苏镇江212013 [2]海南大学海南省精细化工重点实验室,海南海口570228

出　　处：《光谱学与光谱分析》2013年第10期2736-2739,共4页Spectroscopy and Spectral Analysis

基　　金：国家自然科学基金项目(21261008/21166008);江苏省科技支撑计划项目(SBE201077304);江苏大学高级人才基金项目(11JDG124)资助

摘　　要：合成了窄分子量分布低聚壳聚糖(CS20)修饰的四(4-羧基苯基)锰(Ⅱ)卟啉(Mn-TCPP)功能配合物(Mn-TCPP-CS20)作为一种潜在的磁共振成像(MRI)造影剂。发现该锰基卟啉-壳聚糖配合物(Mn-TCPPCS20)有良好的水溶性和分子结构稳定性。通过红外(FTIR)、紫外(UV-Vis)、质谱(MS)及电感耦合等离子体发射仪(ICP-AES)对其结构进行了表征。表明,低聚壳聚糖CS20通过酰胺键与Mn-TCPP共价链接。初步研究了功能配合物Mn-TCPP-CS20作为潜在的MRI造影剂的体外弛豫性能,发现其纵向弛豫率r1(6.11mmol-1·l·s-1)高于商用的MRI造影剂Gd-DTPA(r1=3.59mmol-1·l·s-1),且在同等条件下体外成像效果更优。Mn-TCPP-CS20可作为潜在的具有组织靶向性的MRI造影剂。The functional complex Mn-TCPP-CS20 as a potential magnetic resonance imaging （MRI） contrast agent was synthe- sized through tetra（4-carboxyphenyl） Mn（ Ⅱ ）-porphyrin （Mn-TCPP） modified by CS20, which was low degree of polymerization and narrow distribution. The results showed that Mn-TCPP-CS20 had good water-solubility and structural stability. The chemi- cal structures of the products were characterized with Fourier transform infrared spectra （FTIR）, UV-Vis spectra, mass spec- trum （MS） and inductively coupled plasma atomic emission spectrometry （ICP-AES）. The results showed that Mn-TCPP was successfully linked to CS20 by an amide function. The relaxation properties in vitro of the functional complex Mn-TCPP-CS20 as the potential MRI contrast agent were preliminarily studied. It was found that the longitudinal relaxivity （rl） of the synthesized Mn-TCPP-CS20 （6. 11 mmo1-1 . L .s-1 ） was higher than that of the commercial contrast agent Gd-DTPA （r1 =3. 59 mmo1-1 . L . s-1 ）. Besides, the imaging effect of Mn-TCPP-CS20 was superior to that of Gd-DTPA in the same condition. These studies suggested that Mn-TCPP-CS20 has the advantage of becoming a potential tissue-targeting contrast agent.

关 键 词：低聚壳聚糖 卟啉 造影剂 弛豫性能 

分 类 号：O657.3[理学—分析化学]